Situating the default-mode network along a principal gradient of macroscale cortical organization
Situating the default-mode network along a principal gradient of macroscale cortical organization
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DOI：
10.1073/pnas.1608282113
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发表时间：
2016-11-01
影响因子：
11.1
通讯作者：
Smallwood, Jonathan
中科院分区：
文献类型：
--
作者：
Margulies, Daniel S.;Ghosh, Satrajit S.;Smallwood, Jonathan
了解认知结构是如何从皮质的地形组织中产生的，是神经科学的一个主要目标。以前的工作已经描述了局部功能梯度，从知觉和运动区延伸到代表更抽象功能的皮质区域，但仍然缺乏结构和功能之间联系的总体框架。在这里，我们证明了由人类和猕猴的连接性数据分解所揭示的主梯度是由一端提供主要感觉/运动功能的区域和另一端的跨模式区域锚定的，在人类中，这些区域被称为默认模式网络(DMN)。这些DMN区域沿皮质表面显示出最大的测地线距离，并且与初级感觉/运动形态标志的距离精确相等。主梯度还为多个大规模网络提供了一个组织空间框架，并在功能荟萃分析中表征了从单峰活动到异峰活动的谱。综上所述，这些观察提供了大脑皮层地形图组织的特征，并表明DMN在认知中的作用可能源于它在层级结构中的一个极端位置，允许它处理与即时感觉输入无关的跨模式信息。
Understanding how the structure of cognition arises from the topographical organization of the cortex is a primary goal in neuroscience. Previous work has described local functional gradients extending from perceptual and motor regions to cortical areas representing more abstract functions, but an overarching framework for the association between structure and function is still lacking. Here, we show that the principal gradient revealed by the decomposition of connectivity data in humans and the macaque monkey is anchored by, at one end, regions serving primary sensory/motor functions and at the other end, transmodal regions that, in humans, are known as the default-mode network (DMN). These DMN regions exhibit the greatest geodesic distance along the cortical surface-and are precisely equidistant-from primary sensory/motor morphological landmarks. The principal gradient also provides an organizing spatial framework for multiple large-scale networks and characterizes a spectrum from unimodal to heteromodal activity in a functional metaanalysis. Together, these observations provide a characterization of the topographical organization of cortex and indicate that the role of the DMN in cognition might arise from its position at one extreme of a hierarchy, allowing it to process transmodal information that is unrelated to immediate sensory input.