Bone regeneration induced by adenoviral vectors carrying til‐1/Cbfa1 genes implanted with biodegradable porous materials in animal models of osteonecrosis of the femoral head
Bone regeneration induced by adenoviral vectors carrying til‐1/Cbfa1 genes implanted with biodegradable porous materials in animal models of osteonecrosis of the femoral head
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DOI：
10.1002/term.72
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发表时间：
2008-03
影响因子：
3.3
通讯作者：
Shinsuke Sakai;Miki Tamura;H. Mishima;H. Kojima;T. Uemura
中科院分区：
文献类型：
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作者：
Shinsuke Sakai;Miki Tamura;H. Mishima;H. Kojima;T. Uemura
股骨头特发性骨坏死（ION）需要一种新的骨再生方法。核心结合因子 α1 (Cbfa1) 于 1997 年被报道为成骨细胞分化最重要的转录因子。影响骨形成的转录因子的转基因可能是骨再生的有用工具。本研究的目的是探讨携带Cbfa1基因的腺病毒载体植入可生物降解的多孔材料对ION动物模型骨形成的影响。通过植入携带 Cbfa1 基因的腺病毒载体，实现了大骨缺损的稳健、快速的骨再生。这些结果表明，Cbfa1 基因诱导快速成骨细胞分化，并且可生物降解支架成功地充当 Cbfa1 基因的递送载体，因为它们在体内诱导成骨修复，甚至在坏死骨中也是如此。版权所有 © 2008 约翰·威利父子有限公司
A new approach for bone regeneration is needed for idiopathic osteonecrosis of the femoral head (ION). Core binding factor α1 (Cbfa1) was reported in 1997 as the most important transcription factor for osteoblastic differentiation. The transgenics of transcription factors affecting bone formation might be useful tools for the bone regeneration. The purpose of this study was to investigate the effects of the implantation of adenoviral vectors carrying Cbfa1 genes implanted with biodegradable porous materials on bone formation in an animal model of ION. Robust and rapid bone regeneration in large bone defects was achieved with the implantation of adenoviral vectors carrying Cbfa1 genes. These results suggest that the Cbfa1 genes induce a rapid osteoblastic differentiation and the biodegradable scaffold successfully functioned as a delivery vehicle for the Cbfa1 gene, as they induced osteogenic repair in vivo, even in necrotic bone. Copyright © 2008 John Wiley & Sons, Ltd.