Characterization of diabetes-related traits in MSM and JF1 mice on high-fat diet
Characterization of diabetes-related traits in MSM and JF1 mice on high-fat diet
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DOI：
10.1016/j.jnutbio.2004.05.001
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发表时间：
2004-10-01
影响因子：
5.6
通讯作者：
Horio, F
中科院分区：
文献类型：
--
作者：
Kobayashi, M;Ohno, T;Horio, F
我们研究了高脂饮食对日本Fancy小鼠1（JF 1）、MSM和C57 BL/6 J（B6 J）小鼠糖尿病相关性状的影响。MSM和JF 1小鼠来自Mus musculus molossinus。B6 J是一种常用的实验室菌株，其绝大多数基因组片段来源于小家鼠和小家鼠，易患高脂饮食诱导的2型糖尿病。当喂食实验室食物时，没有一种菌株显示出糖尿病或肥胖的症状。在高脂肪饮食下，JF 1小鼠出现糖耐量受损、高血糖、高胰岛素血症和肥胖。与喂食高脂肪饮食的JF 1小鼠相比，喂食高脂肪饮食的B6 J小鼠轻度发展了这些糖尿病相关的特征。喂食高脂饮食的JF 1小鼠被归类为患有2型糖尿病，并且易患高脂饮食诱导的糖尿病和肥胖症。另一方面，MSM小鼠对高脂饮食诱导的糖尿病有抵抗力。这些结果表明，JF 1株，其独特的遗传来源，是一个有用的新的高脂饮食诱导的糖尿病和肥胖的动物模型。使用JF 1小鼠的进一步研究将有助于阐明高脂肪饮食对人类糖尿病和肥胖的作用。(C)2004年爱思唯尔公司All rights reserved.
We examined the effect of a high-fat diet on the diabetes-related traits of the Japanese Fancy mouse 1 (JF1), MSM, and C57BL/6J (B6J) mice. MSM and JF1 mice were derived from Mus musculus molossinus. B6J is a commonly used laboratory strain, with the vast majority of genome segments derived from Mus musculus domesticus and Mus musculus musculus, and is susceptible to high-fat diet-induced type 2 diabetes. None of the strains showed symptoms of diabetes or obesity when fed a laboratory chow diet. Under a high-fat diet, JF1 mice developed impaired glucose tolerance, hyperglycemia, hyperinsulinemia, and obesity. B6J mice fed a high-fat diet mildly developed these diabetes-related traits compared to JF1 mice fed a high-fat diet. JF1 mice fed a high-fat diet were classified as having type 2 diabetes and were susceptible to high-fat diet-induced diabetes and obesity. On the other hand, MSM mice were resistant to high-fat diet-induced diabetes. These results indicate that the JF1 strain, with its unique genetic origin, is a useful new animal model of high-fat diet-induced diabetes and obesity. Further investigations using JF1 mice will help to clarify the role of the high-fat diet on human diabetes and obesity. (C) 2004 Elsevier Inc. All rights reserved.