Tibial dyschondroplasia of chickens induced by Fusarochromanone, a mycotoxin.
Tibial dyschondroplasia of chickens induced by Fusarochromanone, a mycotoxin.
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由 Fusarochromanone（一种霉菌毒素）引起的鸡胫骨软骨发育不良。
作者：
W. Wu;M. Cook;Q. Chu;E. Smalley
试验用添加真菌毒素褐黄酮（FC）的实用肉鸡起始日粮饲喂3周。在哈伯德肉鸡中，最高试验剂量FC （75 ppm）可使体重降低33%，对绵羊红细胞的体液反应降低34% ~ 50%，并使胫骨软骨发育不良（TD）的发生率增加到100%。中剂量（35 ppm）显著增加了两种肉鸡（Hubbard和Indian River）的TD发病率，但其对绵羊红细胞体液反应的影响在几项实验中并不一致。最低膳食浓度大于20ppm才会显著增加TD的发病率。饲粮中过量铜或锌（200ppm）可减轻FC对TD的影响。而铜依赖性铜蓝蛋白和超氧化物歧化酶的活性不受FC的影响。FC-或thiram诱导的TD软骨矿物分布与1日龄增生性胚胎软骨核心（较少K和Mn）不同。FC未引起来角鸡TD。
Chicks were fed for 3 weeks a practical broiler starter diet amended with fusarochromanone (FC), a mycotoxin. In Hubbard broiler chicks, the highest test dose of FC (75 ppm) suppressed body weight by 33% and humoral response to sheep erythrocytes by 34% to 50%, and increased the incidence of tibial dyschondroplasia (TD) to 100%. The intermediate dose (35 ppm) significantly increased the incidence of TD in both types of broiler chicks (Hubbard and Indian River), but its effect on humoral response to sheep erythrocytes was not consistent across several experiments. A minimum dietary concentration greater than 20 ppm was required to significantly increase the incidence of TD. Excessive dietary copper or zinc (200 ppm) alleviated the effect of FC on TD. However, activities of copper-dependent ceruloplasmin and superoxide dismutase was not affected by FC. Cartilage mineral profiles in FC- or Thiram-induced TD differed from that of 1-day-old hypertrophic embryonic cartilage core (less K and Mn). FC did not induce TD in leghorn chicks.
DOI：
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发表时间：
1985
期刊：
The American journal of pathology
影响因子：
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作者：
Hargest,TE;Gay,CV;Leach,RM
通讯作者：
Leach,RM