Evidence for beneficial effects of vitamin E.
Evidence for beneficial effects of vitamin E.
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DOI：
10.3904/kjim.2015.30.5.571
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Niki E
中科院分区：
文献类型：
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作者：
Niki E
氧化应激和脂质过氧化与动脉粥样硬化和脂肪肝等多种疾病的发病机制有关，因此抗氧化剂在预防和治疗这些疾病中的作用受到了广泛关注。特别是，维生素E，最重要的亲脂性自由基清除抗氧化剂的影响，已被广泛研究。许多体外、动物和流行病学研究都报告了积极的结果，但大规模随机对照干预研究和荟萃分析产生了不一致且往往令人失望的结果。在本综述文章中，讨论了维生素E的作用和作用，并考虑了决定维生素E治疗结果的因素。当在正确的时间和适当的持续时间给予维生素E时，维生素E应使因自由基而经历氧化应激的受试者受益。
Oxidative stress and lipid peroxidation have been implicated in the pathogenesis of various diseases, including atherosclerosis and fatty liver diseases, and consequently the role of antioxidants in the prevention and treatment of such diseases has received much attention. In particular, the effects of vitamin E, the most important lipophilic radical-scavenging antioxidant, have been investigated extensively. Many in vitro, animal, and epidemiological studies have reported positive results, but large-scale randomized controlled intervention studies and meta-analyses have produced inconsistent and often disappointing results. In the present review article, the role and action of vitamin E are discussed, with consideration of the factors that determine the outcome of vitamin E treatment. Vitamin E should benefit subjects experiencing oxidative stress due to free radicals when administered at the correct time and for an appropriate duration.