Orientation preference patterns in mammalian visual cortex: A wire length minimization approach
Orientation preference patterns in mammalian visual cortex: A wire length minimization approach
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DOI：
10.1016/s0896-6273(01)00223-9
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发表时间：
2001-02-01
期刊：
影响因子：
16.2
通讯作者：
Chklovskii, DB
中科院分区：
文献类型：
--
作者：
Koulakov, AA;Chklovskii, DB
在许多哺乳动物的视觉皮层中，方向偏好沿着皮层表面沿着平滑地变化，除了像风车和骨折这样的奇点。这些奇点存在的原因仍然难以捉摸，这表明它们是发育的产物。我们发现，奇点减少了一些连接规则的皮层内神经元连接的长度。因此，风车和骨折可能是进化的适应，使皮质体积保持在最低限度。线长最小化方法表明，方向偏好图的物种间差异反映了皮质内神经元回路的差异，从而得出了可实验检验的预测。我们讨论我们的模型的应用方向偏好地图。
In the visual cortex of many mammals, orientation preference changes smoothly along the cortical surface, with the exception of singularities such as pinwheels and fractures. The reason for the existence of these singularities has remained elusive, suggesting that they are developmental artifacts. We show that singularities reduce the length of intracortical neuronal connections for some connection rules. Therefore, pinwheels and fractures could be evolutionary adaptations keeping cortical volume to a minimum. Wire length minimization approach suggests that interspecies differences in orientation preference maps reflect differences in intracortical neuronal circuits, thus leading to experimentally testable predictions. We discuss application of our model to direction preference maps.