Familial aggregation and covariation of diseases in a Japanese rural community: Comparison of stomach cancer with other diseases
Familial aggregation and covariation of diseases in a Japanese rural community: Comparison of stomach cancer with other diseases
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DOI：
10.1016/s1047-2797(97)00077-x
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发表时间：
1997-10-01
影响因子：
5.6
通讯作者：
Aoki, K
中科院分区：
文献类型：
--
作者：
Toyoshima, H;Hayashi, S;Aoki, K
目得：通过对某农村社区2,769名居民胃癌、脑卒中、高血压、糖尿病、肺结核等疾病家族史及生活方式的问卷调查，探讨了疾病的家族聚集性及家族共变（84%的人口普查）。家族聚集性的强度通过比值比（OR）来显示比较了兄弟姐妹患有上述疾病之一的家庭与父母中至少有一方患有这种疾病的家庭的数量，而在那些家庭中，他们都没有这样做。先证者被分为两组进行分析：55岁以下的“年轻组”和55岁以上的“老年组”。结果：胃癌的OR值在青年组中最低，无显著性差异，仅在老年组中有显著性差异（2.2，p < 0.05）。中风、高血压和肺结核的OR在年轻组为4.5-5.1（p < 0.05），但在老年组降至2.3-3.2。随着年龄的增长，糖尿病从3.9增加到5.7（p < 0.05）。吸烟相关的OR趋势不受过去吸烟的影响。胃癌与糖尿病呈边缘性家族协变，与高血压呈边缘性逆协变。高血压与中风和糖尿病有家族性协变。结论：在调查的疾病中，胃癌的家族聚集性最弱。结果提示胃癌与糖尿病和低血压可能有共同的家族病因。(C)1997年爱思唯尔科学公司
PURPOSE: We investigated familial aggregation as well as familial covariation of diseases by means of a questionnaire survey dealing with family histories of stomach cancer, stroke, hypertension, diabetes and tuberculosis as well as life style among 2,769 inhabitants of a rural community (84% of census population).METHODS: The strength of familial aggregation was shown by an odds ratio (OR) that compared the number of families in which siblings suffered from one of the above diseases among families in which at least one parent suffered from it, and among families in which neither did. Probands were divided into two groups for analysis: an under 55 ''young group,'' and a 55-and-older ''old group.''RESULTS: The OR for stomach cancer was lowest and insignificant in the young group, and significant (2.2, p < 0.05) only in the old group. The OR for stroke, hypertension, and tuberculosis was 4.5-5.1 (p < 0.05) in the young group but decreased to 2.3-3.2 in the old group. Diabetes increased from 3.9 to 5.7 p < 0.05) with advancing age. Age-related OR trends were not affected by exposure to cigarette smoke in the past. Stomach cancer showed a borderline familial covariation with diabetes and a borderline inverse covariation with hypertension. Hypertension showed a familial covariation with stroke and diabetes.CONCLUSIONS: Among the investigated diseases, familial aggregation was weakest for stomach cancer. The results suggest that stomach cancer may share a common familial etiologic factor with diabetes and hypotension. (C) 1997 Elsevier Science Inc.