Let's Talk About Sex-Biological Sex Is Underreported in Biomaterial Studies.
Let's Talk About Sex-Biological Sex Is Underreported in Biomaterial Studies.
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DOI：
10.1002/adhm.202001034
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发表时间：
2021-01
影响因子：
10
通讯作者：
Allen JB
中科院分区：
文献类型：
--
作者：
James BD;Guerin P;Allen JB
精准医疗旨在更好地个性化医疗保健。它要求生物材料设计用于特定患者的生理特征。为了使这成为现实，生物材料的研究和开发必须解决生物性别的差异。更具体地说，生物材料的设计应具有优化的特性，并适合男性和女性患者。在分析来自七个著名的生物材料期刊的研究文章时，性别作为一个生物变量在绝大多数体外生物材料研究中缺失。根据调查，仅10.3%的时间报告了原代细胞培养物的性别。促成这一趋势的是，商业供应商在购买时不披露细胞系性别的信息，从而使细胞系偏向于一种性别或另一种性别;研究人员在已发表的研究中不传达此相关信息;许多期刊政策对报告细胞系特征几乎没有要求。忽略这些有价值的信息会导致对性别特异性细胞-生物材料相互作用的理解存在差距，并导致研究结果对某一性别或另一性别产生偏见。为了遏制这种令人担忧的趋势，并使精确的生物材料成为现实，将需要生物材料领域通过更广泛地报道细胞性别来“谈论性别”。自1999年以来，性别已被认为是生物医学研究中的一个重要生物变量;然而，20多年后，它仍然没有在许多生物材料文献中报道。研究人员、细胞供应商和期刊都有机会扭转这一趋势。为了使精确的生物材料成为现实，将需要生物材料研究界通过更广泛地报告细胞性别来积极应对这一挑战。
Precision medicine aims to better individualize healthcare. It requires that biomaterials be designed for the physiological characteristics of a specific patient. To make this a reality, biomaterials research and development must address differences of biological sex. More specifically, biomaterials should be designed with properties optimized and appropriate for male and female patients. In analyzing research articles from seven prominent biomaterials journals, sex as a biological variable is missing from an overwhelming majority of in vitro biomaterial studies. From the survey, the reporting of the sex of primary cell cultures happened only 10.3% of the time. Contributing to this trend is that commercial vendors bias cell lines toward one sex or another by not disclosing information of cell line sex at the time of purchase; researchers do not communicate this pertinent information in published studies; and many journal policies have little to no requirements for reporting cell line characteristics. Omitting this valuable information leads to a gap in the understanding of sex-specific cell-biomaterial interactions and it creates a bias in research findings towards one sex or another. To curb this concerning trend and make precision biomaterials a reality will require the biomaterials field to “talk about sex” by reporting cell sex more broadly. Since 1999, sex has been recognized as a significant biological variable in biomedical research; yet, 20+ years later it remains unreported in much of the biomaterials literature. Opportunities exist for investigators, cell vendors, and journals to reverse this trend. To make precision biomaterials a reality will require the biomaterials research community to actively address this challenge by reporting cell sex more broadly.
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影响因子：
4.3
作者：
Cimino M;Gonçalves RM;Barrias CC;Martins MCL
通讯作者：
Martins MCL
DOI：
10.1056/nejmsr1809937
发表时间：
2019-08-15
期刊：
The New England journal of medicine
影响因子：
--
作者：
All of Us Research Program Investigators;Denny JC;Rutter JL;Goldstein DB;Philippakis A;Smoller JW;Jenkins G;Dishman E
通讯作者：
Dishman E
影响因子：
4.1
作者：
Bharadwaj, Vimala N.;Copeland, Connor;Stabenfeldt, Sarah E.
通讯作者：
Stabenfeldt, Sarah E.
影响因子：
41.2
作者：
Chaudhuri O;Gu L;Klumpers D;Darnell M;Bencherif SA;Weaver JC;Huebsch N;Lee HP;Lippens E;Duda GN;Mooney DJ
通讯作者：
Mooney DJ
影响因子：
2.6
作者：
Butler, JE;Hammond, TH;Gray, SD
通讯作者：
Gray, SD