Dose-Dependent Changes in Auditory Sensory Gating in the Prefrontal Cortex of the Cynomolgus Monkey.
Dose-Dependent Changes in Auditory Sensory Gating in the Prefrontal Cortex of the Cynomolgus Monkey.
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食蟹猴前额皮质听觉感觉门控的剂量依赖性变化
DOI：
10.12659/msm.898938
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发表时间：
2016-05-24
期刊：
影响因子：
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通讯作者：
Jianhong W
中科院分区：
文献类型：
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作者：
Huang H;Ya J;Wu Z;Wen C;Zheng S;Tian C;Ren H;Carlson S;Yu H;Chen F;Jianhong W
感觉门控通常被描述为一种过滤在时间上紧密重复的无关信息的能力，对于更显著信息的选择、处理和存储至关重要。本研究旨在测试在给猴子注射溴隐亭、氟哌啶醇和苯环己哌啶（PCP）后，麻醉状态下前额叶皮质（PFC）的感觉门控效应。
我们利用声音诱发的听觉诱发电位来检测食蟹猴PFC在使用氟哌啶醇、溴隐亭和PCP治疗期间的感觉门控。头皮电极放置在双侧PFC以及双侧颞叶、双侧顶叶和枕叶。给予溴隐亭（0.313毫克/千克、0.625毫克/千克和1.25毫克/千克）、氟哌啶醇（0.001毫克/千克、0.01毫克/千克和0.05毫克/千克）以及N - 甲基 - D - 天冬氨酸受体拮抗剂PCP（0.3毫克/千克）会影响感觉门控。
我们证明了以下几点：（1）给予中等剂量的溴隐亭会破坏右侧颞叶的感觉门控（N100），而低剂量和高剂量的溴隐亭均未损害门控。（2）低剂量氟哌啶醇会损害右侧前额叶皮质的门控。中等剂量氟哌啶醇会破坏左侧枕叶的感觉门控。高剂量氟哌啶醇对感觉门控无明显影响。（3）PCP会损害左侧顶叶的门控。
我们的研究表明，信息处理受多巴胺能系统调节，该系统可能在前额叶皮质中起重要作用。多巴胺能系统以剂量和区域依赖的方式影响感觉门控，这可能会调节因新信息而接受进一步处理的不同阶段。
Sensory gating, often described as the ability to filter out irrelevant information that is repeated in close temporal proximity, is essential for the selection, processing, and storage of more salient information. This study aimed to test the effect of sensory gating under anesthesia in the prefrontal cortex (PFC) of monkeys following injection of bromocriptine, haloperidol, and phencyclidine (PCP). We used an auditory evoked potential that can be elicited by sound to examine sensory gating during treatment with haloperidol, bromocriptine, and PCP in the PFC in the cynomolgus monkey. Scalp electrodes were located in the bilateral PFC and bilateral temporal, bilateral parietal, and occipital lobes. Administration of bromocriptine (0.313 mg/kg, 0.625 mg/kg, and 1.25 mg/kg), haloperidol (0.001 mg/kg, 0.01 mg/kg, and 0.05 mg/kg), and the N-methyl-D-aspartic acid receptor antagonist PCP (0.3 mg/kg) influenced sensory gating. We demonstrated the following: (1) Administration of mid-dose bromocriptine disrupted sensory gating (N100) in the right temporal lobe, while neither low-dose nor high-dose bromocriptine impaired gating. (2) Low-dose haloperidol impaired gating in the right prefrontal cortex. Mid-dose haloperidol disrupted sensory gating in left occipital lobe. High-dose haloperidol had no obvious effect on sensory gating. (3) Gating was impaired by PCP in the left parietal lobe. Our studies showed that information processing was regulated by the dopaminergic system, which might play an important role in the PFC. The dopaminergic system influenced sensory gating in a dose- and region-dependent pattern, which might modulate the different stages that receive further processing due to novel information.