Genetic association between atopic disease and osteoarthritis.
Genetic association between atopic disease and osteoarthritis.
复制标题
特应性疾病和骨关节炎之间的遗传关联。
DOI：
10.1016/j.joca.2023.11.003
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发表时间：
2024
影响因子：
7
通讯作者：
Ostrom,Quinn
中科院分区：
文献类型：
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作者：
Baker,MatthewC;Robinson,WilliamH;Ostrom,Quinn
目的评价特应性疾病的遗传风险与骨性关节炎(OA)的关系。方法采用1000个基因组计划欧洲样本作为全基因组LD模式的参考，进行连锁不平衡(LD)分数回归。特应性疾病特征的汇总统计数据来自英国生物库。我们建立了特应性疾病的骨性关节炎和性状之间的成对遗传相关性，以估计性状(Rg)和每个性状的遗传力之间的遗传相关性。采用孟德尔随机化(MR)方法对特应性相关性状与骨性关节炎的相关性进行统计分析，采用逆方差加权(IVW)、MR-Egger、最大似然估计法、加权中位数和加权模型。结果哮喘全基因组遗传结构与所有骨性关节炎性状呈显著正相关。使用IVW(随机效应)，哮喘与膝骨性关节炎之间存在显著关联((优势比)OR=1.04，95%(可信区间)CI 1.01-1.08，P=0.0169)。经固定效应检验，膝关节骨关节炎与变态反应性疾病(OR=1.07，95%CI1.01~1.14，P=0.0342)、过敏性鼻炎(OR1.07，95%CI1.00~1.13，P=0.0368)、哮喘(OR=1.04，95%CI1.01~1.07，P=0.0139)、以及任何部位的骨性关节炎与哮喘(OR=1.02，95%CI1.00~1.04，P=0.04)显著相关。结论我们发现哮喘的总体遗传结构与骨性关节炎之间存在显著的相关性，并且具有与哮喘和过敏性鼻炎相关的基因变异的患者发生骨性关节炎的风险增加；大多数情况下，这种风险是膝骨性关节炎的发生。这些结果支持哮喘和/或过敏性鼻炎与膝骨性关节炎之间的因果关系。
ObjectivesTo evaluate the association between genetically determined risk for atopic disease and osteoarthritis (OA).MethodsWe performed linkage disequilibrium (LD) score regression using 1000 Genomes Project European samples as a reference for patterns of genome-wide LD. Summary statistics for atopic disease traits were obtained from the UK Biobank. We generated a pairwise genetic correlation between OA and traits for atopic disease to estimate the genetic correlation between traits (rg) and heritability for each trait. The association between atopy-related traits and OA was examined using Mendelian randomization (MR) on summary statistics; we reported inverse-variance weighted (IVW), MR-Egger, maximum likelihood estimation, weighted median, and weighted mode.ResultsThere was a significant positive correlation between the genome-wide genetic architecture of asthma and all OA traits. Using the IVW (random effects), there was a significant association between asthma and knee OA ((odds ratio) OR = 1.04, 95% (confidence interval) CI 1.01–1.08, p = 0.0169). Using IVW (fixed effects), significant associations were identified between knee OA and allergic disease (OR = 1.07, 95% CI 1.01–1.14, p = 0.0342), allergic rhinitis (OR = 1.07, 95% CI 1.00–1.13, p = 0.0368), and asthma (OR = 1.04, 95% CI 1.01–1.07, p = 0.0139), as well as for OA at any site and asthma (OR = 1.02, 95% CI 1.00–1.04, p = 0.0166).ConclusionsWe found a significant correlation between the overall genetic architecture of asthma and OA, as well as an increased risk of developing OA in patients with genetic variants associated with asthma and allergic rhinitis; predominately, this risk was for the development of knee OA. These results support a causal relationship between asthma and/or allergic rhinitis and knee OA.