A novel detection technique of polyamide binding sites by photo-induced electron transfer in BrU substituted DNA
A novel detection technique of polyamide binding sites by photo-induced electron transfer in BrU substituted DNA
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DOI：
10.1039/c5cc05104e
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发表时间：
2015-01-01
影响因子：
4.9
通讯作者：
Sugiyama, Hiroshi
中科院分区：
文献类型：
--
作者：
Saha, Abhijit;Hashiya, Fumitaka;Sugiyama, Hiroshi
我们报道了Bru取代DNA的光化学作为一个通用的平台来研究芘连接的吡咯咪唑多酰胺(PIP)的结合位置。结果表明，该方法可用于常规的聚酰胺结合位点的筛选。
We report the photochemistry of BrU substituted DNA as a versatile platform to investigate the binding sites of pyrene conjugated pyrrole imidazole polyamides (PIPs). The results suggest that the approach can be used on a routine basis for the screening of polyamide binding sites.