Perivascular adipose tissue: more than just structural support.
Perivascular adipose tissue: more than just structural support.
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DOI：
10.1042/cs20110151
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发表时间：
2012-01
期刊：
影响因子：
--
通讯作者：
Webb RC
中科院分区：
文献类型：
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作者：
Szasz T;Webb RC
The perivascular adipose tissue (PVAT) has recently been recognized as a novel factor in vascular biology, with implications in the pathophysiology of cardiovascular disease. Composed mainly of adipocytes, PVAT releases a wide range of biologically active molecules that modulate the vascular smooth muscle cell contraction, proliferation and migration. PVAT exerts an anticontractile effect in various vascular beds which seems to be mediated by yet elusive PVAT-derived relaxing factor or factors (PVRF). Considerable progress has been made on deciphering the nature and mechanisms of action of PVRF, and the PVRFs proposed until now are reviewed here. However, complex pathways seem to regulate the PVAT function and more than one mechanism is probably responsible for PVAT actions in vascular biology. This review will describe our current knowledge on the structure and function of PVAT, with a focus on its role in modulating vascular tone. Potential involvements of PVAT dysfunction in obesity, hypertension and atherosclerosis will be highlighted.
