Repetitive transcranial magnetic stimulation activates specific regions in rat brain
Repetitive transcranial magnetic stimulation activates specific regions in rat brain
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DOI：
10.1073/pnas.95.26.15635
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发表时间：
1998-12-22
影响因子：
11.1
通讯作者：
Rupp, F
中科院分区：
文献类型：
--
作者：
Ji, RR;Schlaepfer, TE;Rupp, F
重复经颅磁刺激（rTMS）是一种非侵入性的技术，在大脑中诱导电流。虽然rTMS正在评估作为一种可能的替代电休克治疗难治性抑郁症，很少有人知道的激活模式诱导大脑中的rTMS。我们比较了大鼠脑中的即时早期基因表达rTMS和电休克刺激后，一个良好的电休克治疗的动物模型。我们的研究结果表明，在抑郁症动物模型中有效的条件下，rTMS诱导的即刻早期基因表达模式与电惊厥刺激不同。特别是，rTMS在丘脑室旁核（PVT）和参与昼夜节律调节的其他区域引起强烈的神经反应。PVT中的反应与刺激探头相对于头部的方向无关。这种反应的一部分可能是由于直接激活，因为重复的磁刺激也会激活大脑切片中的PVT神经元。
Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive technique to induce electric currents in the brain. Although rTMS is being evaluated as a possible alternative to electroconvulsive therapy for the treatment of refractory depression, little is known about the pattern of activation induced in the brain by rTMS. We have compared immediate early gene expression in rat brain after rTMS and electroconvulsive stimulation, a well-established animal model for electroconvulsive therapy. Our result shows that rTMS applied in conditions effective in animal models of depression induces different patterns of immediate-early gene expression than does electroconvulsive stimulation. In particular, rTMS evokes strong neural responses in the paraventricular nucleus of the thalamus (PVT) and in other regions involved in the regulation of circadian rhythms. The response in PVT is independent of the orientation of the stimulation probe relative to the head. Part of this response is likely because of direct activation, as repetitive magnetic stimulation also activates PVT neurons in brain slices.