Apomorphine-induced nausea in humans: release of vasopressin and pancreatic polypeptide.
Apomorphine-induced nausea in humans: release of vasopressin and pancreatic polypeptide.
复制标题
阿扑吗啡引起的人类恶心：加压素和胰多肽的释放。
DOI：
10.1016/s0016-5085(88)80020-9
复制
发表时间：
1988
期刊：
影响因子：
29.4
通讯作者：
O'Dorisio,TM
中科院分区：
文献类型：
--
作者：
Feldman,M;Samson,WK;O'Dorisio,TM
基于对动物和人类的研究，已经表明恶心激活下丘脑-神经垂体系统，导致催产素或加压素的循环浓度增加。这些研究的目的是确定人类恶心是否与神经垂体激素或各种肠胰肽（血管活性肠多肽、P物质或胰多肽）的循环浓度增加相关。阿扑吗啡静脉注射引起的恶心，与7名受试者血浆加压素浓度增加5倍至75倍有关（平均增加41倍），而血浆催产素水平没有变化。此外，恶心与血浆胰多肽浓度增加7倍至16倍（平均增加9倍），血浆血管活性肠多肽或P物质水平无变化。在1例难治性恶心受试者中，阿扑吗啡未增加血浆加压素或胰多肽浓度。这些研究表明，人类的恶心与加压素和胰多肽的释放有关。
Based on studies in animals and humans, it has been suggested that nausea activates the hypothalamo-neurohypophyseal system with resultant increases in circulating concentrations of oxytocin or vasopressin. The purpose of these studies was to determine in humans whether nausea is associated with increases in circulating concentrations of neurohypophyseal hormones or various enteropancreatic peptides (vasoactive intestinal polypeptide, substance P, or pancreatic polypeptide). Nausea, induced by intravenous infusion of apomorphine, was associated with fivefold to 75-fold increases in plasma vasopressin concentrations in 7 subjects (mean increase, 41-fold), with no change in plasma oxytocin levels. Furthermore, nausea was associated with sevenfold to 16-fold increases in plasma pancreatic polypeptide concentrations (mean increase, ninefold), with no change in plasma levels of vasoactive intestinal polypeptide or substance P. In 1 subject refractory to nausea, there was no increase in plasma vasopressin or pancreatic polypeptide concentrations with apomorphine. These studies indicate that nausea in humans is associated with vasopressin and pancreatic polypeptide release.