Physiological modeling of isoprene dynamics in exhaled breath
Physiological modeling of isoprene dynamics in exhaled breath
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DOI：
10.1016/j.jtbi.2010.09.028
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发表时间：
2010-12-21
影响因子：
2
通讯作者：
Amann, Anton
中科院分区：
文献类型：
--
作者：
King, Julian;Koc, Helin;Amann, Anton
人体呼吸中含有大量的内源性挥发性有机化合物（VOCs）虽然对这些痕量气体的诊断潜力和一般医学相关性的研究在相当大的规模上进行，但迄今为止很少关注呼吸水平和潜在全身浓度之间的定量关系的合理分析。与异戊二烯相关的潮气末呼吸动力学的全面建模研究，该研究可作为低溶性血液传播VOC类的典型示例。在测力计挑战下呼出气的时间测量揭示了异戊二烯输出响应于通气和灌注变化的特征变化。推断在运动条件期间呼吸异戊二烯变化的主要部分可归因于潜在储存和产生部位的增加的部分灌注，导致在身体活动开始时较高水平的混合静脉血浓度。在这种情况下，我们的模型是迈向异戊二烯肝外组织来源新指南的第一步，异戊二烯的呼吸气体分析，预计将有助于进一步研究与这种重要化合物相关的呼出、储存、运输和生物转化过程（C）2010 Elsevier Ltd版权所有
Human breath contains a myriad of endogenous volatile organic compounds (VOCs) which are reflective of ongoing metabolic or physiological processes While research Into the diagnostic potential and general medical relevance of these trace gases is conducted on a considerable scale little focus has been given so far to a sound analysis of the quantitative relationships between breath levels and the underlying systemic concentrations This paper is devoted to a thorough modeling study of the end-tidal breath dynamics associated with isoprene which serves as a paradigmatic example for the class of low-soluble blood-borne VOCsReal-time measurements of exhaled breath under an ergometer challenge reveal characteristic changes of isoprene output in response to variations in ventilation and perfusion Here a valid compartmental description of these profiles is developed By comparison with experimental data it is inferred that the major part of breath isoprene variability during exercise conditions can be attributed to an Increased fractional perfusion of potential storage and production sites leading to higher levels of mixed venous blood concentrations at the onset of physical activity In this context, various lines of supportive evidence for an extrahepatic tissue source of isoprene are presentedOur model is a first step towards new guidelines for the breath gas analysis of isoprene and is expected to aid further investigations regarding the exhalation storage transport and biotransformation processes associated with this important compound (C) 2010 Elsevier Ltd All rights reserved