YKL-40 in asthmatic patients, and its correlations with exacerbation, eosinophils and immunoglobulin E
YKL-40 in asthmatic patients, and its correlations with exacerbation, eosinophils and immunoglobulin E
复制标题
哮喘患者中的 YKL-40 及其与病情加重、嗜酸性粒细胞和免疫球蛋白 E 的相关性
DOI：
10.1183/09031936.00034409
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发表时间：
2010-04-01
影响因子：
24.3
通讯作者：
Xiu, Q.
中科院分区：
文献类型：
--
作者：
Tang, H.;Fang, Z.;Xiu, Q.
几丁质酶样蛋白YKL-40结合几丁质但缺乏几丁质酶活性，已被发现是哮喘的病因或生物标志物。本研究的目的是探讨中国哮喘患者血清YKL-40水平是否升高，并确定其与急性发作、血清总免疫球蛋白（IG）E、外周血嗜酸性粒细胞百分比和肺功能的相关性。我们定量了哮喘患者血清YKL-40水平、总IgE水平和外周血嗜酸性粒细胞百分比，以及我们医院周围社区的对照组。哮喘患者的肺功能也进行了测量。我们的数据显示，血清YKL-40水平显着升高，哮喘患者与对照组相比，当哮喘受试者分层，血清YKL-40水平在急性发作组高于那些在稳定和对照组。此外，血清YKL-40水平与血清总IgE水平和外周血嗜酸性粒细胞百分比呈正相关，但与肺功能呈负相关。因此，我们得出结论，YKL-40在中国哮喘患者血清中的含量增加，其水平与急性发作相关，表明血清YKL-40的高水平可能是哮喘急性发作的生物学特征。
The chitinase-like protein YKL-40, which binds chitin but lacks chitinase activity, has been found to be either the cause or a biomarker for asthma. The aim of our study was to investigate whether serum YKL-40 levels are increased in Chinese patients with asthma and identify its correlation to acute exacerbation, total serum immunoglobulin (Ig)E, the percentage of peripheral blood eosinophils and lung function. We quantified serum YKL-40 levels, total IgE levels and peripheral blood eosinophil percentages in patients with asthma, as well as in controls from the communities surrounding our hospital. The lung function of asthma subjects was also measured. Our data showed that the serum YKL-40 levels were significantly elevated in patients with asthma compared with controls and, when the asthma subjects were stratified, serum YKL-40 levels in the exacerbation group were higher than those in the stable and control groups. In addition, serum YKL-40 levels correlated positively with total serum IgE levels and the percentage of peripheral blood eosinophils, but correlated inversely with lung functions. Thus, we conclude that YKL-40 is found in increased quantities in the serum of Chinese patients with asthma, and its level correlates with exacerbation attacks, indicating that high levels of serum YKL-40 may be a biological characteristic of the exacerbation of asthma.