Tissue Distribution of Boron Compounds in Relation to Neutron-Capture Therapy of Cancer.∗
Tissue Distribution of Boron Compounds in Relation to Neutron-Capture Therapy of Cancer.∗
复制标题
硼化合物的组织分布与癌症中子捕获疗法的关系。*
DOI：
10.3181/00379727-86-21010
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发表时间：
1954
影响因子：
--
通讯作者：
W. Sweet
中科院分区：
文献类型：
--
作者：
H. Locksley;W. Sweet
1)近年来原子堆在人脑肿瘤中子俘获治疗中的应用引起了人们对硼化合物生物学行为的关注。2)在小鼠和人身上报道的研究表明，硼砂和硼酸在体内被迅速吸收和分布。各种器官和肿瘤的吸收描述了一系列相似的曲线，即浓度上升得越快，峰值就越高、越早。所有被研究的组织，除了大脑，在30分钟内达到峰值。硼酸盐作为与尿素和硫酸盐一类的“低阈值物质”由肾脏迅速排出，在小鼠血液中的清除过程以大约65分钟的指数半衰期进行。3)注射后至少2小时内，正常小鼠组织中硼酸盐浓度在18 ~ 700 μg/g体重范围内与剂量成正比。4)在平衡分布中，在肾切除小鼠中研究，硼酸盐均匀分布在整个体内水，在细胞内隔室中有10%至20%的过量结合。这种过量在大脑中的结合比在其他组织中更顽强，似乎是造成这些化合物毒性的原因。5)对肿瘤与周围正常组织浓度比的影响因素的研究表明，除脑外的恶性肿瘤，硼-中子治疗前景渺茫。
Summary and Conclusions 1) Recent application of the atomic pile to the neutron-capture therapy of human brain tumors has focussed attention on the biological behavior of boron compounds. 2) Studies reported in mice and man indicate that borax and boric acid are rapidly absorbed and distributed throughout the body. Uptake by the various organs and tumor describes a family of similar curves such that the faster the rise in concentration, the higher and earlier is the peak. All tissues studied, except brain, reach a peak by 30 minutes. Borate is rapidly excreted by the kidneys as a “low-threshold substance” in a class with urea and sulphate, and clearance from the blood in mice proceeds with an exponential half-time of approximately 65 minutes. 3) Concentrations of borate in the tissues of normal mice are directly proportional to dosage for at least 2 hours after injection over a range of 18 to 700 μg/g body weight. 4) At equilibrium distribution, studied in nephrectomized mice, borate is uniformly distributed throughout the body water, with a 10 to 20% excess bound in the intracellular compartment. This excess is bound more tenaciously in brain than in other tissues and appears to be responsible for the toxicity of these compounds. 5) Study of the factors determining the concentration ratio between neoplasm and surrounding normal tissues indicates that boron-neutron treatment offers little promise for malignant tumors other than those of the brain.