European surveillance for enterovirus D68 during the emerging North-American outbreak in 2014
European surveillance for enterovirus D68 during the emerging North-American outbreak in 2014
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DOI：
10.1016/j.jcv.2015.07.296
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发表时间：
2015-10-01
影响因子：
8.8
通讯作者：
Lina, Bruno
中科院分区：
文献类型：
--
作者：
Poelman, Randy;Schuffenecker, Isabelle;Lina, Bruno
背景：2014年8月和9月，北美出现了与严重呼吸道疾病相关的意想不到的肠道病毒D68(EV-D68)感染集群。9月，欧洲疾病预防和控制中心(ECDC)要求欧洲国家加强对出现严重呼吸道症状的病例进行肠道病毒检测和分型的呼吸道样本筛查。目的：通过对临床标本进行回顾性和前瞻性的实验室分析，提供欧洲EV-D68流行病学的详细情况。研究设计：2014年7月1日至12月1日，在欧洲临床病毒学学会(ESCV)和欧洲疾病预防控制中心(ECDC)的支持下，发起了一项在欧洲筛查EV-D68的倡议，并对检测到的病毒VP1区进行了序列测定，用于系统发育分析。结果：来自欧洲17个国家的51个实验室的42个研究所分析了17,248份标本，产生了389份EV-D68阳性样本(2.26%)。每个国家的阳性样本比例从0%到25%不等。这些感染主要导致轻微的呼吸道疾病，主要在出现喘息的幼儿和免疫功能受损的成年人中发现。在欧洲发现的病毒与北美流行的病毒在基因上非常相似，大多数(83%)可归类为B分支。除3例急性弛缓性麻痹(AFP)病例、1例死亡和有限的ICU入院外，没有严重病例报告。结论：欧洲研究表明，EV-D68于2014年夏秋两季在欧洲流行，与北美疫情相比，疾病负担中等，病原学特征不同。(C)2015年提交人。爱思唯尔出版公司(Elsevier B.V.)
Background: In August and September 2014, unexpected clusters of enterovirus-D68 (EV-D68) infections associated with severe respiratory disease emerged from North-America. In September, the European Centre for Disease Prevention and Control (ECDC) asked European countries to strengthen respiratory sample screening for enterovirus detection and typing in cases with severe respiratory presentations. Objectives: To provide a detailed picture of EV-D68 epidemiology in Europe by conducting a retrospective and prospective laboratory analysis of clinical specimens.Study design: An initiative supported by the European Society for Clinical Virology (ESCV) and ECDC was launched to screen for EV-D68 in respiratory specimens between July 1st and December 1st 2014 in Europe and to sequence the VP1 region of detected viruses for phylogenetic analytic purposes.Results: Forty-two institutes, representing 51 laboratories from 17 European countries, analyzed 17,248 specimens yielding 389 EV-D68 positive samples (2.26%) in 14 countries. The proportion of positive samples ranged between 0 and 25% per country. These infections resulted primarily in mild respiratory disease, mainly detected in young children presenting with wheezing and in immuno-compromised adults. The viruses detected in Europe are genetically very similar to those of the North-American epidemic and the majority (83%) could be assigned to clade B. Except for 3 acute flaccid paralysis (AFP) cases, one death and limited ICU admissions, no severe cases were reported.Conclusions: The European study showed that EV-D68 circulated in Europe during summer and fall of 2014 with a moderate disease burden and different pathogenic profile compared to the North-American epidemic. (C) 2015 The Authors. Published by Elsevier B.V.