Diagnostic Usefulness of the Protein Energy Wasting Score in Prevalent Hemodialysis Patients
Diagnostic Usefulness of the Protein Energy Wasting Score in Prevalent Hemodialysis Patients
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DOI：
10.1053/j.jrn.2018.05.002
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发表时间：
2018-11-01
影响因子：
3.2
通讯作者：
Carrero, Juan J.
中科院分区：
文献类型：
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作者：
Anton-Perez, Gloria;Santana-del-Pino, Angelo;Carrero, Juan J.
目的：研究是否由国际肾脏营养与代谢学会提出的评分定义的蛋白质能量消耗（PEW）综合征进行dialys.Design和方法：横断面研究，包括468流行的血液透析患者从西班牙加那利群岛的诊断效度。使用线性和逻辑回归分析，个体PEW综合征标准和PEW综合征类别的数量与PEW的其他客观标志物相关：主观整体评估、握力、生物阻抗评估的身体成分和高敏C反应蛋白水平。研究参与者（34%为女性）的中位年龄为66岁，维持透析37个月，50%为糖尿病患者。大约23%的患者患有PEW（>= 3种PEW类别），68%的患者有PEW风险（1-2种PEW类别）。低前白蛋白是最常见的紊乱（52%的病例），其次是低白蛋白（46%）和低蛋白质摄入量（35%）。在PEW综合征类别中，患者的透析时间较长，肌酐、甘油三酯和转铁蛋白较低（趋势P
Objective: To study whether the score proposed by the International Society of Renal Nutrition and Metabolism to define the protein energy wasting (PEW) syndrome has diagnostic validity in patients undergoing dialysis.Design and methods: Cross-sectional study including 468 prevalent hemodialysis patients from Canary Islands, Spain. Individual PEW syndrome criteria and the number of PEW syndrome categories were related to other objective markers of PEW using linear and logistic regression analyses: subjective global assessment, handgrip strength, bioimpedance-assessed body composition, and levels of high-sensitivity C-reactive protein.Results: Study participants (34% women) had a median age of 66 years, 37 months of maintenance dialysis, and 50% were diabetics. About 23% of patients had PEW (>= 3PEW categories), and 68% were at risk of PEW (1-2 PEW categories). Low prealbumin was the most frequently found derangement (52% of cases), followed by low albumin (46%), and low protein intake (35%). Across higher number of PEW syndrome categories, patients showed a longer dialysis vintage and had lower creatinine, triglycerides, and transferrin (P for trend