A Novel in vivo System to Test Bronchodilators.
A Novel in vivo System to Test Bronchodilators.
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DOI：
10.16966/2470-3176.120
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发表时间：
2017-03
期刊：
影响因子：
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通讯作者：
Ledford JG
中科院分区：
文献类型：
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作者：
Addison KJ;Morse J;Robichaud A;Daines MO;Ledford JG
哮喘的发病率和严重程度在全球范围内持续上升。β-受体激动剂是哮喘管理中最常用的处方治疗药物，但对某些哮喘患者亚群的疗效较低，并且长期持续使用的副作用令人担忧。开发新型哮喘治疗药物的需求突出了对标准化方法的需求，以使用相关的体内动物模型有效地筛选和测试潜在的支气管保护化合物。在这里，我们描述了一种经验证的方法，测试潜在的治疗化合物在屋尘螨激发的动物模型中诱导支气管收缩期间的速效功效。
The incidence and severity of asthma continue to rise worldwide. β-agonists are the most commonly prescribed therapeutic for asthma management but have less efficacy for some subsets of asthmatic patients and there are concerns surrounding the side effects from their long-term persistent use. The demand to develop novel asthma therapeutics highlights the need for a standardized approach to effectively screen and test potential bronchoprotective compounds using relevant in vivo animal models. Here we describe a validated method of testing potential therapeutic compounds for their fast-acting efficacy during the midst of an induced bronchoconstriction in a house dust mite challenged animal model.