Leuko-polymersomes
Leuko-polymersomes
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DOI：
10.1039/b717821b
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发表时间：
2008-01-01
影响因子：
3.4
通讯作者：
Bates, Frank S.
中科院分区：
文献类型：
--
作者：
Hammer, Daniel A.;Robbins, Gregory P.;Bates, Frank S.
聚合物囊泡是其膜由自组装的两亲性嵌段共聚物组成的囊泡。嵌段共聚物化学的合成控制提供了聚合物囊泡功能的有利多样性，范围从可调的材料强度、疏水和亲水药物和光学染料的上级包封以及容易的官能化。我们已经利用聚合物体的可调性来制造白细胞聚合物体：具有白细胞粘附特性的聚合物体。通过用生物素官能化囊泡外壳上的末端基团，我们已经使用模块化抗生物素蛋白-生物素化学来附着粘附配体，所述粘附配体模仿白细胞用于在血管的快速流体流动中实现粘附的两个关键粘附途径-选择素和整合素。我们证明，粘附是特定的，并支持在流体动力学流速，白细胞粘附。我们设想使用这种颗粒来监测或治疗炎症、癌症和心血管疾病。
Polymersomes are vesicles whose membranes are comprised of self-assembled amphiphilic block co-polymers. Synthetic control of block co-polymer chemistry provides an advantageous diversity of polymersome functions, ranging from tunable materials strength, superior encaspulation of hydrophobic and hydrophilic drugs and optical dyes, and facile functionalization. We have exploited polymersome tunability to make leuko-polymersomes: polymersomes with the adhesive properties of leukocytes. By functionalizing the terminal groups on the outer shell of the vesicle with biotin, we have used modular avidin-biotin chemistry to attach adhesion ligands that mimic the two critical adhesion pathways that leukocytes utilize to achieve adhesion in the fast fluid flow of blood vessels-selectins and integrins. We demonstrate that adhesion is specific and is supported at hydrodynamic flow rates at which leukocytes adhere. We envision the use of such particles for monitoring or treating inflammation, cancer and cardiovascular disease.