Methods and characteristics of published network meta-analyses using individual patient data: protocol for a scoping review.
Methods and characteristics of published network meta-analyses using individual patient data: protocol for a scoping review.
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DOI：
10.1136/bmjopen-2014-007103
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发表时间：
2015-04-29
期刊：
影响因子：
2.9
通讯作者：
Straus SE
中科院分区：
文献类型：
--
作者：
Veroniki AA;Soobiah C;Tricco AC;Elliott MJ;Straus SE
个体患者数据(IPD)荟萃分析(MA)在对试验中的患者特征使用标准化标准方面比聚合MA更具优势，并允许对干预措施的亚组影响进行可靠的调查。网络荟萃分析(NMA)允许在综合分析中比较多种治疗方法，并在几种相互竞争的治疗方法中确定最佳治疗方法，包括那些从未在面对面研究中进行比较的治疗方法。将IPD纳入NMA可以防止由于几种偏见(如聚合偏见)而产生的误导性推断。IPD-NMA方法在医疗保健中的应用已开始出现在医学期刊上。我们的目标是对现有的IPD-NMA方法进行范围审查，并总结它们的特性。我们还旨在描述经验IPD-NMA的特征，并检查他们的结果是如何报道的。我们将搜索从最初到2014年10月的相关电子数据库(如MEDLINE)、灰色文献和谷歌。范围审查将考虑报告IPD-NMA完成情况、描述一种方法或报告IPD-NMA方法质量的已发表和未发表的论文。我们将包括任何定量研究(例如，实验、准实验、观察性研究)的IPD-NMA。两名审稿人将独立筛选标题、摘要和全文文章，并完成数据摘要。预期成果将是迄今为止完成的所有综合方案和国家方案的集合，以及对其方法和成果报告的说明。我们将创建汇总表，提供所纳入研究的特点和各种方法。量化数据(例如，患者数量)将按中位数和IQR汇总，分类数据(例如，效果大小的类型)将按频率和百分比汇总。不需要伦理批准，因为我们的研究不会包括机密的参与者数据和干预措施。我们将通过开放获取、同行评议的出版物来传播我们的成果。
Individual patient data (IPD) meta-analysis (MA) offers advantages over aggregate MA of using standardised criteria for patient characteristics across trials, and allowing reliable investigation of subgroup effects of interventions. Network meta-analysis (NMA) allows for the comparison of multiple treatments in a comprehensive analysis and the determination of the best treatment among several competing treatments, including those that have never been compared in a head-to-head study. Including IPD in NMA may enable the prevention of misleading inferences due to several biases, such as aggregation bias. Application of IPD-NMA methods in healthcare have begun to appear in medical journals. Our objective is to conduct a scoping review of existing IPD-NMA methods, and summarise their properties. We also aim to describe the characteristics of empirical IPD-NMAs, and examine how their results are reported. We will search relevant electronic databases from inception until October 2014 (eg, MEDLINE), grey literature, and Google. The scoping review will consider published and unpublished papers that report completion of an IPD-NMA, describe a method, or report the methodological quality of IPD-NMA. We will include IPD-NMA of any quantitative study (eg, experimental, quasiexperimental, observational studies). Two reviewers will independently screen titles, abstracts and full-text articles, and will complete data abstraction. The anticipated outcome will be a collection of all the IPD-NMAs completed to date, and a description of their methods and reporting of results. We will create summary tables providing the characteristics of the included studies, and the various methods. Quantitative data (eg, number of patients) will be summarised by medians and IQRs, and categorical data (eg, type of effect size) by frequencies and percentages. Ethical approval is not required as our study will not include confidential participant data and interventions. We will disseminate our results through an open access, peer-reviewed publication.
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DOI：
10.1136/bmj.b2535
发表时间：
2009-07-21
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Moher D;Liberati A;Tetzlaff J;Altman DG;PRISMA Group
通讯作者：
PRISMA Group
影响因子：
2
作者：
Saramago, Pedro;Sutton, Alex J.;Manca, Andrea
通讯作者：
Manca, Andrea
影响因子：
9.8
作者：
Jansen, Jeroen P.
通讯作者：
Jansen, Jeroen P.
影响因子：
4.5
作者：
Jansen, Jeroen P.;Fleurence, Rachael;Cappelleri, Joseph C.
通讯作者：
Cappelleri, Joseph C.
仿真评估间接和混合治疗比较方法的统计特性。
影响因子：
4
作者：
Song F;Clark A;Bachmann MO;Maas J
通讯作者：
Maas J