The expression of vesicular glutamate transporters defines two classes of excitatory synapse
The expression of vesicular glutamate transporters defines two classes of excitatory synapse
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DOI：
10.1016/s0896-6273(01)00344-0
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发表时间：
2001-08-02
期刊：
影响因子：
16.2
通讯作者：
Edwards, RH
中科院分区：
文献类型：
--
作者：
Fremeau, RT;Troyer, MD;Edwards, RH
谷氨酸的量子释放取决于其转运到突触小泡中。最近的研究表明，以前与跨质膜吸收无机磷酸盐有关的蛋白质可催化突触小泡对谷氨酸的吸收。然而，只有一部分谷氨酸神经元表达这种囊泡谷氨酸转运蛋白 (VGLUT1)。我们现在报道，缺乏 VGLUT1 的兴奋性神经元表达一种密切相关的蛋白质，该蛋白质也与磷酸盐转运有关。与 VGLUT1 一样，该蛋白定位于突触小泡并充当囊泡谷氨酸转运蛋白 (VGLUT2)。 VGLUT1 和 2 的互补表达定义了两类不同的兴奋性突触。
The quantal release of glutamate depends on its transport into synaptic vesicles. Recent work has shown that a protein previously implicated in the uptake of inorganic phosphate across the plasma membrane catalyzes glutamate uptake by synaptic vesicles. However, only a subset of glutamate neurons expresses this vesicular glutamate transporter (VGLUT1). We now report that excitatory neurons lacking VGLUT1 express a closely related protein that has also been implicated in phosphate transport. Like VGLUT1, this protein localizes to synaptic vesicles and functions as a vesicular glutamate transporter (VGLUT2). The complementary expression of VGLUT1 and 2 defines two distinct classes of excitatory synapse.