Water soluble polymers in tumor targeted delivery
Water soluble polymers in tumor targeted delivery
复制标题
DOI：
10.1016/s0168-3659(01)00330-3
复制
发表时间：
2001-07-06
影响因子：
10.8
通讯作者：
Peterson, CM
中科院分区：
文献类型：
--
作者：
Kopecek, J;Kopecková, P;Peterson, CM
使用水溶性聚合物进行抗癌药物递送的基本原理包括：克服某些形式的多药耐药性的潜力。由于增强的渗透性和保留（EPR）效应，生物可识别性，在实体瘤中优先蓄积。和针对性。卵巢癌治疗新模式在实验动物模型中的应用。其将化学疗法和光动力疗法与聚合物结合的抗癌药物相结合。研究和临床应用以及大分子治疗的未来发展方向进行了讨论。(C)2001爱思唯尔科技有限公司。保留所有权利。
The rationales for the use of water soluble polymers for anticancer drug delivery include: the potential to overcome some forms of multidrug; resistance. preferential accumulation in solid tumors due to enhanced permeability and retention (EPR) effect, biorecognizability. and targetability. The utility of a novel paradigm for the treatment of ovarian carcinoma in an experimental animal model. which combines chemotherapy and photodynamic therapy with polymer-bound anticancer drugs is explained. Research and clinical applications as well as directions for the future development of macromolecular therapeutics are discussed. (C) 2001 Elsevier Science B.V. All rights reserved.