Parents' Ages at Birth and Risk of Adult-onset Hematologic Malignancies Among Female Teachers in California
Parents' Ages at Birth and Risk of Adult-onset Hematologic Malignancies Among Female Teachers in California
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DOI：
10.1093/aje/kwq090
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发表时间：
2010-06-15
影响因子：
5
通讯作者：
Wang, Sophia S.
中科院分区：
文献类型：
--
作者：
Lu, Yani;Ma, Huiyan;Wang, Sophia S.
虽然父母出生时的高龄与乳腺癌和前列腺癌的风险增加有关，但很少有研究探讨其对成人散发性恶性血液病的影响。作者在前瞻性加州教师研究中招募了110，999名年龄在22-84岁之间的符合条件的女性，研究了女性出生时父母年龄与血液恶性肿瘤风险的关系。在1995年至2007年期间，819名没有恶性血液病家族史的女性被诊断为偶发性淋巴瘤、白血病（主要是急性髓性白血病）或多发性骨髓瘤。多变量校正的考克斯比例风险模型提供了相对风险的估计值和95%置信区间。在调整种族和出生顺序后，父亲年龄与非霍奇金淋巴瘤呈正相关（年龄>= 40岁与< 25岁的相对风险= 1.51，95%置信区间：1.08，2.13; P趋势= 0.01）。对母亲年龄的进一步调整并没有实质性地改变这种关联。相比之下，当统计模型中包含父亲年龄时，与高龄母亲（>= 40岁）相关的非霍奇金淋巴瘤风险升高变为零。未观察到与急性髓性白血病或多发性骨髓瘤相关。父亲高龄可能在非霍奇金淋巴瘤病因中起作用。潜在的致病机制包括从头基因突变，异常的父系基因印记，或端粒/端粒酶生物学。
Although advanced parental age at one's birth has been associated with increased risk of breast and prostate cancers, few studies have examined its effect on adult-onset sporadic hematologic malignancies. The authors examined the association of parents' ages at women's births with risk of hematologic malignancies among 110,999 eligible women aged 22-84 years recruited into the prospective California Teachers Study. Between 1995 and 2007, 819 women without a family history of hematologic malignancies were diagnosed with incident lymphoma, leukemia (primarily acute myeloid leukemia), or multiple myeloma. Multivariable-adjusted Cox proportional hazards models provided estimates of relative risks and 95% confidence intervals. Paternal age was positively associated with non-Hodgkin lymphoma after adjustment for race and birth order (relative risk for age >= 40 vs. < 25 years = 1.51, 95% confidence interval: 1.08, 2.13; P-trend = 0.01). Further adjustment for maternal age did not materially alter the association. By contrast, the elevated non-Hodgkin lymphoma risk associated with advanced maternal age (>= 40 years) became null when paternal age was included in the statistical model. No association was observed for acute myeloid leukemia or multiple myeloma. Advanced paternal age may play a role in non-Hodgkin lymphoma etiology. Potential etiologic mechanisms include de novo gene mutations, aberrant paternal gene imprinting, or telomere/telomerase biology.