Default network interactivity during mentalizing about known others is modulated by age and social closeness.
Default network interactivity during mentalizing about known others is modulated by age and social closeness.
复制标题
在对已知他人进行心智化过程中，默认的网络交互性受到年龄和社交亲密程度的调节。
DOI：
10.1093/scan/nsaa067
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发表时间：
2020
影响因子：
4.2
通讯作者：
Spreng,RNathan
中科院分区：
文献类型：
--
作者：
Laurita,AnneC;DuPre,Elizabeth;Ebner,NatalieC;Turner,GaryR;Spreng,RNathan
在年轻人中，对已知他人的认知涉及默认网络，由社会亲密度调节的不同大脑反应。虽然默认网络的功能完整性随着年龄的增长而变化，但很少有研究调查这些变化如何影响跨亲密程度的已知他人的表征。采用功能磁共振成像（fMRI）对年轻（N= 29, 16名女性）和年长（N= 27, 12名女性）的成年人进行特征判断。多变量分析（偏最小二乘）确定了两个年龄组中特征判断的默认网络激活。对于年轻人来说，浪漫伴侣和自我判断不同于其他水平的社会亲密关系，它们与默认网络和突出网络的活动有关。相比之下，默认的网络互动不受老年人社会亲密度的调节。在两个功能连通性分析中，两个年龄组在特征判断过程中都表现出背侧和腹侧内侧前额叶皮层以及其他默认网络区域之间的连通性。然而，年龄较大的成年人（而不是年轻人）也显示出大脑内侧和外侧前额叶区域之间的功能耦合增加，这种耦合不会因已知其他区域的类别而变化。在老年人中，对他人的思维涉及大脑的默认区和额叶区，而这种耦合在社会亲密关系中调节得很差。
In young adults, mentalizing about known others engages the default network, with differential brain response modulated by social closeness. While the functional integrity of the default network changes with age, few studies have investigated how these changes impact the representation of known others, across levels of closeness. Young (N= 29, 16 females) and older (N= 27, 12 females) adults underwent functional magnetic resonance imaging (fMRI) scanning while making trait judgments for social others varying in closeness. Multivariate analyses (partial least squares) identified default network activation for trait judgments across both age cohorts. For young adults, romantic partner and self-judgments differed from other levels of social closeness and were associated with activity in default and salience networks. In contrast, default network interactivity was not modulated by social closeness for older adults. In two functional connectivity analyses, both age groups demonstrated connectivity between dorsal and ventral medial prefrontal cortex and other default network regions during trait judgments. However older, but not young, adults also showed increased functional coupling between medial and lateral prefrontal brain regions that did not vary by category of known other. Mentalizing about others engages default and frontal brain regions in older adulthood, and this coupling is poorly modulated by social closeness.