CELL RECOGNITION DURING NEURONAL DEVELOPMENT
CELL RECOGNITION DURING NEURONAL DEVELOPMENT
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DOI：
10.1126/science.6474176
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
THOMAS, JB
中科院分区：
文献类型：
--
作者：
GOODMAN, CS;BASTIANI, MJ;THOMAS, JB
昆虫胚胎的神经系统相对简单，为研究神经元发育过程中细胞识别的细胞和分子机制提供了一个模型。这种方法可以利用蚱蜢胚胎的易接近细胞和果蝇的易接近基因。确定的神经元的生长锥表达特定的轴突表面的选择性亲和力，这种特异性引起的定型模式的选择性fasciculation共同的两个物种。这些和其他结果表明，在早期的发展细胞谱系和细胞相互作用导致的差异表达的细胞识别分子的表面上的小子集的胚胎神经元的轴突选择性地彼此成束。单克隆抗体揭示了果蝇胚胎中的表面分子，其表达与这一预测相关。现在应该有可能分离出编码这些潜在细胞识别分子的基因，并通过在果蝇中使用分子遗传学方法来测试它们的功能。
Insect embryos, with their relatively simple nervous systems, provide a model system with which to study the cellular and molecular mechanisms underlying cell recognition during neuronal development. Such an approach can take advantage of the accessible cells of the grasshopper embryo and the accessible genes ofDrosophila. The growth cones of identified neurons express selective affinities for specific axonal surfaces; such specificities give rise to the stereotyped patterns of selective fasciculation common to both species. These and other results suggest that early in development cell lineage and cell interactions lead to the differential expression of cell recognition molecules on the surfaces of small subsets of embryonic neurons whose axons selectively fasciculate with one another. Monoclonal antibodies reveal surface molecules in theDrosophilaembryo whose expression correlates with this prediction. It should now be possible to isolate the genes encoding these potential cell recognition molecules and to test their function through the use of molecular genetic approaches inDrosophila.