Correlative analyses of notch signaling with resveratrol-induced differentiation and apoptosis of human medulloblastoma cells
Correlative analyses of notch signaling with resveratrol-induced differentiation and apoptosis of human medulloblastoma cells
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Notch信号与白藜芦醇诱导人髓母细胞瘤细胞分化和凋亡的相关性分析
DOI：
10.1016/j.neulet.2008.04.012
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发表时间：
2008-06
影响因子：
2.5
通讯作者：
Liu, Nan
中科院分区：
文献类型：
--
作者：
Wang, Qjan;Li, Hong;Chen, Xiao-Yan;Zhang, Kai-Li;Liu, Jia;Kong, Qing-You;Wu, Mo-Li;Liu, Nan
Notch信号的改变似乎与髓母细胞瘤（MB）的形成有关，白藜芦醇具有抗髓母细胞瘤的作用。然而，白藜芦醇对MB细胞Notch信号传导的影响尚未得到描述。这个问题在这里通过检查Notch 1和Notch 2状态在三个MB细胞系与白藜芦醇治疗和不治疗。Notch 1和Notch 2在正常情况下均存在于3种细胞的胞浆中，白藜芦醇沿着其表达上调，并伴随着细胞的分化、凋亡和Hes 1核转位增强。然而，用γ-seacretase抑制剂DAPT和L-685，458阻断Notch酶裂解既不中断白藜芦醇引起的细胞事件，也不影响MB细胞生长。这些结果表明，Notch信号通路与白藜芦醇诱导的分化和凋亡相关性不大，可能不是MB细胞的普遍关键因素。
Altered Notch signaling seems linked with medulloblastoma (MB) formation and resveratrol exhibits anti-medulloblastoma effects. However, the influence of resveratrol in Notch signaling of MB cells has not been described. This issue was addressed here by checking Notch1 and Notch2 statuses in three MB cell lines with and without resveratrol treatment. Notch1 and Notch2 were detected in the cytoplasm of three cell lines under normal condition, which were up-regulated by resveratrol along with differentiation, apoptosis and enhanced Hes1 nuclear translocation. Nevertheless, blockage of Notch enzymatic cleavage with γ-seacretase inhibitors, DAPT and L-685,458, neither interrupted resveratrol-caused cellular events nor affected MB cell growth. These results demonstrate that Notch signaling has little relevance with resveratrol-induced differentiation and apoptosis and may not be a universal critical factor of MB cells.
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影响因子：
4.4
作者：
Manna, SK;Mukhopadhyay, A;Aggarwal, BB
通讯作者：
Aggarwal, BB
影响因子：
3.9
作者：
P. Zhang;Hong Li;Mo-li Wu;Xiao-yan Chen;Qing-you Kong;Xiao-Wei Wang;Yuan Sun;S. Wen;Jia Liu
通讯作者：
P. Zhang;Hong Li;Mo-li Wu;Xiao-yan Chen;Qing-you Kong;Xiao-Wei Wang;Yuan Sun;S. Wen;Jia Liu
影响因子：
2
作者：
J. Liu;Lee-Jae Guo;Yang Luo;Jun-wei Li;H. Li
通讯作者：
J. Liu;Lee-Jae Guo;Yang Luo;Jun-wei Li;H. Li
影响因子：
5.4
作者：
J. Liu;L. Guo;L. Jun-wei;N. Liu;H. Li
通讯作者：
J. Liu;L. Guo;L. Jun-wei;N. Liu;H. Li
DOI：
10.1016/s1040-1741(08)79172-3
发表时间：
2008
期刊：
Yearbook of Oncology
影响因子：
--
作者：
R. Arceci
通讯作者：
R. Arceci