Age- and sex-specific differences in immune responses to BNT162b2 COVID-19 and live-attenuated influenza vaccines in UK adolescents.
Age- and sex-specific differences in immune responses to BNT162b2 COVID-19 and live-attenuated influenza vaccines in UK adolescents.
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DOI：
10.3389/fimmu.2023.1248630
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发表时间：
2023
影响因子：
7.3
通讯作者：
Goulder, Philip
中科院分区：
文献类型：
--
作者：
Jay, Cecilia;Adland, Emily;Csala, Anna;Lim, Nicholas;Longet, Stephanie;Ogbe, Ane;Ratcliff, Jeremy;Sampson, Oliver;Thompson, Craig P.;Turtle, Lance;Barnes, Eleanor;Dunachie, Susanna;Klenerman, Paul;Carroll, Miles;Goulder, Philip
了解COVID-19保护相关因素的关键是评估不同人口群体的疫苗诱导免疫。年轻人死于COVID-19的风险较低，女性的风险低于男性，而且女性通常对疫苗接种产生更强的免疫反应。我们在青少年队列（n = 34，年龄12-16岁）中研究了两剂BNT162b2辉瑞COVID-19疫苗的免疫反应，该年龄组先前显示对同一疫苗的免疫反应明显高于年轻人。研究了青少年对BNT162b2和成人的反应；并评估其他因素的影响，如性别、学校中持续的SARS-CoV-2感染，以及之前接触过在年轻人中高水平传播的地方性冠状病毒。与此同时，我们能够评估对共同施用减毒流感活疫苗的免疫反应。对34名青少年在接种COVID-19和流感疫苗前后采集的血液样本进行了SARS-CoV-2特异性IgG、中和抗体和SARS-CoV-2和地方性乙型冠状病毒特异性细胞免疫检测。还评估了流感疫苗中含有的针对流感谱系的IgG。先前感染的青少年在一次剂量后发现了强大的中和反应，infection-naïve青少年需要两次剂量。如前所述，通过MSD v-plex检测，接种过疫苗的青少年对SARS-CoV-2 Spike的总IgG应答显著高于接种过BNT162b2疫苗的成年人（32-52岁）（infection-naïve, 49,696比33,339;p = 0.03；先前感染过SARS-CoV-2的青少年，743,691比269,985;p <0.0001）。没有证据表明女性比男性有更强的疫苗诱导免疫力。这些发现可能是由于引入了新的mRNA疫苗接种平台，产生了与既定趋势不同的免疫模式，并为COVID-19疫苗接种后可能具有保护作用的因素提供了新的见解。
The key to understanding the COVID-19 correlates of protection is assessing vaccine-induced immunity in different demographic groups. Young people are at a lower risk of COVID-19 mortality, females are at a lower risk than males, and females often generate stronger immune responses to vaccination. We studied immune responses to two doses of BNT162b2 Pfizer COVID-19 vaccine in an adolescent cohort (n = 34, ages 12–16), an age group previously shown to elicit significantly greater immune responses to the same vaccine than young adults. Adolescents were studied with the aim of comparing their response to BNT162b2 to that of adults; and to assess the impacts of other factors such as sex, ongoing SARS–CoV–2 infection in schools, and prior exposure to endemic coronaviruses that circulate at high levels in young people. At the same time, we were able to evaluate immune responses to the co-administered live attenuated influenza vaccine. Blood samples from 34 adolescents taken before and after vaccination with COVID-19 and influenza vaccines were assayed for SARS–CoV–2-specific IgG and neutralising antibodies and cellular immunity specific for SARS–CoV–2 and endemic betacoronaviruses. The IgG targeting influenza lineages contained in the influenza vaccine were also assessed. Robust neutralising responses were identified in previously infected adolescents after one dose, and two doses were required in infection-naïve adolescents. As previously demonstrated, total IgG responses to SARS–CoV-2 Spike were significantly higher among vaccinated adolescents than among adults (aged 32–52) who received the BNT162b2 vaccine (comparing infection-naïve, 49,696 vs. 33,339; p = 0.03; comparing SARS-CoV–2 previously infected, 743,691 vs. 269,985; p <0.0001) by the MSD v-plex assay. There was no evidence of a stronger vaccine-induced immunity in females compared than in males. These findings may result from the introduction of novel mRNA vaccination platforms, generating patterns of immunity divergent from established trends and providing new insights into what might be protective following COVID-19 vaccination.
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影响因子：
37.8
作者：
Bozkurt, Biykem;Kamat, Ishan;Hotez, Peter J.
通讯作者：
Hotez, Peter J.
影响因子：
3.7
作者：
Grunau, Brian;Prusinkiewicz, Martin;Asamoah-Boaheng, Michael;Golding, Liam;Lavoie, Pascal M.;Petric, Martin;Levett, Paul N.;Haig, Scott;Barakauskas, Vilte;Karim, Mohammad Ehsanul;Jassem, Agatha N.;Drews, Steven J.;Sediqi, Sadaf;Goldfarb, David M.
通讯作者：
Goldfarb, David M.
DOI：
10.1073/pnas.1321060111
发表时间：
2014-01-14
影响因子：
11.1
作者：
Furman, David;Hejblum, Boris P.;Davis, Mark M.
通讯作者：
Davis, Mark M.
严重的COVID-19，儿童的多系统炎症综合征和川崎疾病：免疫机制，临床表现和管理。
影响因子：
4
作者：
Kabeerdoss J;Pilania RK;Karkhele R;Kumar TS;Danda D;Singh S
通讯作者：
Singh S
DOI：
10.1038/s43587-021-00114-7
发表时间：
2021-09
期刊：
Nature aging
影响因子：
--
作者：
Bartleson JM;Radenkovic D;Covarrubias AJ;Furman D;Winer DA;Verdin E
通讯作者：
Verdin E