Multi-Omics Analysis Reveals the Role of Sigma-1 Receptor in
Multi-Omics Analysis Reveals the Role of Sigma-1 Receptor in
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发表时间：
2023
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通讯作者：
Dong Zhao
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作者：
Yi Liu;Qing Chen;Dong Zhao
Abstract: Takotsubo syndrome (TTS) is a stress-induced cardiomyopathy that presents with sudden.onset of chest pain and dyspneic and cardiac dysfunction as a result of extreme physical or emotional.stress. The sigma-1 receptor (Sigmar1) is a ligand-dependent molecular chaperone that is postulated.to be involved in various processes related to cardiovascular disease. However, the role of Sigmar1.in TTS remains unresolved. In this study, we established a mouse model of TTS using wild-type.and Sigmar1 knockout mice to investigate the involvement of Sigmar1 in TTS development. Our.results revealed that Sigmar1 knockout exacerbated cardiac dysfunction, with a noticeable decrease.in ejection fraction (EF) and fractional shortening (FS) compared to the wild-type model. In terms of.the gut microbiome, we observed regulation of Firmicutes and Bacteroidetes ratios; suppression of.probiotic Lactobacillus growth; and a rise in pathogenic bacterial species, such as Colidextribacter..Metabolomic and transcriptomic analyses further suggested that Sigmar1 plays a role in regulating.tryptophan metabolism and several signaling pathways, including MAPK, HIF-1, calcium signaling,.and apoptosis pathways, which may be crucial in TTS pathogenesis. These findings offer valuable.insight into the function of Sigmar1 in TTS, and this receptor may represent a promising therapeutic.target for TTS
