Variation in the CYP19A1 gene and risk of colon and rectal cancer.
Variation in the CYP19A1 gene and risk of colon and rectal cancer.
复制标题
DOI：
10.1007/s10552-011-9768-x
复制
发表时间：
2011-07
影响因子：
2.3
通讯作者：
Wolff, Roger K.
中科院分区：
文献类型：
--
作者：
Slattery, Martha L.;Lundgreen, Abbie;Herrick, Jennifer S.;Kadlubar, Susan;Caan, Bette J.;Potter, John D.;Wolff, Roger K.
CYP19A1，或芳香酶，影响雌激素代谢酶，并可能影响癌症风险。我们使用基于人群的病例对照研究(结肠癌n=1,574例，对照1,970例；直肠n=791例，对照999例)的数据来检验CYP19A1基因的变异与结直肠癌的风险。4个SNP与结肠癌有统计学意义的关联，4个SNP与直肠癌相关。调整多因素比较后，rs12591359的AA基因型与结肠癌风险增加相关(OR 1.44 95%CI 1.16~1.80)，rs2470144 AA基因型与直肠癌风险降低相关(OR 0.65 95%CI 0.50~0.84)。CIMP+和CIMP+/KRAS2突变的肿瘤与CYP19A1基因突变相关。Rs1961177的CT/TT基因型与MSI+结肠癌发生的可能性显著相关(OR1.77，95%CI 1.26~2.37)。我们观察到，在结肠癌和直肠癌中，NF-κB1和CYP19A1的遗传变异之间存在显著的统计学上的交互作用。我们的数据表明，CYP19A1在结肠癌和直肠癌的发生发展中具有重要作用，雌激素可能通过与炎症相关的机制影响风险。
CYP19A1, or aromatase, influences estrogen-metabolizing enzymes and may influence cancer risk. We examine variation in the CYP19A1 gene and risk of colorectal cancer using data from population-based case–control studies (colon n = 1,574 cases, 1,970 controls; rectal n = 791 cases, 999 controls). Four SNPs were statistically significantly associated with colon cancer and four were associated with rectal cancer. After adjustment for multiple comparisons, the AA genotype of rs12591359 was associated with an increased risk of colon cancer (OR 1.44 95% CI 1.16–1.80) and the AA genotype of rs2470144 was associated with a reduced risk of rectal cancer (OR 0.65 95% CI 0.50–0.84). Variants of CYP19A1 were associated with CIMP+ and CIMP+/KRAS2-mutated tumors. CT/TT genotypes of rs1961177 were significantly associated with an increased likelihood of a MSI+ colon tumor (OR 1.77 95% CI 1.26–2.37). We observed statistically significant interactions between genetic variation in NFκB1 and CYP19A1 for both colon and rectal cancer. Our data suggest the importance of CYP19A1 in the development of colon and rectal cancer and that estrogen may influence risk through an inflammation-related mechanism.
登录
查看更多内容
影响因子：
3.5
作者：
Guo, Yan;Xiong, Dong-Hai;Deng, Hong-Wen
通讯作者：
Deng, Hong-Wen
影响因子：
3.9
作者：
Marino, M.;Galluzzo, P.;Ascenzi, P.
通讯作者：
Ascenzi, P.
影响因子：
158.5
作者：
Chlebowski, RT;Wactawski-Wende, J;Carleton, R
通讯作者：
Carleton, R
影响因子：
2.5
作者：
Fagan, Dedra H.;Yee, Douglas
通讯作者：
Yee, Douglas
影响因子：
6.4
作者：
Samowitz, WS;Curtin, K;Slattery, ML
通讯作者：
Slattery, ML