Delta-catenin affects the localization and stability of p120-catenin by competitively interacting with E-cadherin.
Delta-catenin affects the localization and stability of p120-catenin by competitively interacting with E-cadherin.
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DOI：
10.1007/s10059-010-0030-2
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发表时间：
2010-03
影响因子：
3.8
通讯作者：
Kim, Kwonseop
中科院分区：
文献类型：
--
作者：
Yang, Ilhwan;Chang, Ockyoung;Lu, Qun;Kim, Kwonseop
e -钙粘蛋白是钙粘蛋白家族的一员，是Ca2+依赖性细胞-细胞粘附分子。已知p120-Catenin和δ-catenin结合到E-cadherin相似的近膜区域，并且已知p120-Catenin稳定E-cadherin。然而，p120-catenin和δ-catenin对E-cadherin竞争的作用尚未得到充分解释。在本报告中，我们发现过表达δ-catenin的细胞在细胞-细胞界面处比对照细胞含有更少的p120-catenin，这导致p120-catenin从质膜重新定位到细胞质溶胶。我们发现一个成功结合到e -钙粘蛋白会对另一个的稳定性产生不利影响。
E-cadherin is a member of the cadherin family of Ca2+-dependent cell-cell adhesion molecules. p120-Catenin and δ-catenin are known to bind to similar juxtamembrane regions of E-cadherin, and p120-catenin is known to stabilize E-cadherin. However, the function of competition between p120-catenin and δ-catenin for the E-cadherin has not been fully explained. In this report, we show that cells overexpressing δ-catenin contain less p120-catenin than control cells at cell-cell interface and that this causes the re-localization of p120-catenin from the plasma membrane to the cytosol. We show that successful binding by one to E-cadherin adversely affects the stability of the other.
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DOI：
10.1083/jcb.148.1.189
发表时间：
2000-01-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Thoreson MA;Anastasiadis PZ;Daniel JM;Ireton RC;Wheelock MJ;Johnson KR;Hummingbird DK;Reynolds AB
通讯作者：
Reynolds AB
影响因子：
3.9
作者：
Ki, Hyunkyoung;Oh, Minsoo;Kim, Kwonseop
通讯作者：
Kim, Kwonseop
影响因子：
6.4
作者：
Burger, MJ;Tebay, MA;Gardiner, RA
通讯作者：
Gardiner, RA
影响因子：
7.5
作者：
TAKEICHI, M
通讯作者：
TAKEICHI, M
影响因子：
1.7
作者：
Zhou, JH;Liyanage, U;Kosik, KS
通讯作者：
Kosik, KS