Correlation of serum L-carnitine and dehydro-epiandrosterone sulphate levels with age and sex in healthy adults.
Correlation of serum L-carnitine and dehydro-epiandrosterone sulphate levels with age and sex in healthy adults.
复制标题
健康成人血清左旋肉碱和硫酸脱氢表雄酮水平与年龄和性别的相关性。
DOI：
10.1093/ageing/28.2.211
复制
发表时间：
1999
期刊：
影响因子：
6.7
通讯作者：
Gravenstein,S
中科院分区：
文献类型：
--
作者：
Chiu,KM;Schmidt,MJ;Havighurst,TC;Shug,AL;Daynes,RA;Keller,ET;Gravenstein,S
目的：L肉碱和脱氢表雄酮独立促进线粒体能量代谢。因此，我们想知道是否与年龄相关的L肉碱或脱氢表雄酮缺乏可能是与年龄相关的能量代谢下降的原因。方法：对2 16名20~95岁健康成人的血清L肉碱和脱氢表雄酮的硫代衍生物(DHEAS)水平进行横断面研究。结果：血清DHEAS水平随年龄增长而下降，总肉碱水平随年龄增长而升高(P<；0.0001)。女性的总肉碱和游离肉碱和DHEAS水平低于男性(P<；0.0001)。酯化/游离(E/F)肉碱(与肉碱可获得性呈负相关)在两性中随年龄增长而增加(P=0.012)。结论：肉碱供应减少与DHEAS水平的年龄相关性下降。这些结果与能量代谢随年龄降低与DHEAS水平和肉碱供应有关的假设是一致的。
OBJECTIVES: L-carnitine and dehydro-epiandrosterone (DHEA) independently promote mitochondrial energy metabolism. We therefore wondered if an age-related deficiency of L-carnitine or DHEA may account for the declining energy metabolism associated with age. METHODS: we evaluated serum levels of L-carnitine and the sulphated derivative of DHEA (DHEAS) in cross-sectional study of 216 healthy adults, aged 20-95. RESULTS: serum DHEAS levels declined, while total carnitine levels increased with age (P < 0.0001). Total and free carnitine and DHEAS levels were lower in women than men (P < 0.0001). Esterified/free (E/F) carnitine (inversely related to carnitine availability) increased with age in both sexes (P=0.012). CONCLUSION: reduced carnitine availability correlates with the age-related decline of DHEAS levels. These results are consistent with the hypothesis that decreased energy metabolism with age relates to DHEAS levels and carnitine availability.