Mature B-cell leukemias with more than 55% prolymphocytes: report of 2 cases with Burkitt lymphoma-type chromosomal translocations involving c-myc.
Mature B-cell leukemias with more than 55% prolymphocytes: report of 2 cases with Burkitt lymphoma-type chromosomal translocations involving c-myc.
复制标题
成熟%20B细胞%20白血病%20with%20more%20比%2055%%20幼淋巴细胞：%20报告%20of%202%20cases%20with%20Burkitt%20淋巴瘤型%20染色体%20易位%20涉及%20c-myc。
DOI：
--
复制
发表时间：
2003
影响因子：
4.6
通讯作者：
L. Medeiros
中科院分区：
文献类型：
--
作者：
S. Merchant;E. Schlette;W. Sanger;R. Lai;L. Medeiros
上下文
CONTEXT
The molecular genetic events involved in the pathogenesis of mature B-cell leukemias with more than 55% prolymphocytes are not well characterized. We have encountered 2 such cases in which conventional cytogenetic analysis identified Burkitt lymphoma-type chromosomal translocations involving 8q24.
OBJECTIVE
To assess these 2 cases for involvement of the c-myc gene using fluorescence in situ hybridization analysis with probes specific for the c-myc and immunoglobulin heavy-chain (IgH) genes.
RESULTS
In both cases, conventional cytogenetic analysis demonstrated complex karyotypes, including chromosomal translocations involving 8q24. In case 1, a case of de novo prolymphocytic leukemia, the t(8;14)(q24;q32) was detected. In case 2, a case of chronic lymphocytic leukemia in prolymphocytoid transformation, the t(8;22)(q24;q11) was identified. Fluorescence in situ hybridization studies showed c-myc/IgH fusion signals in case 1, proving the presence of the t(8;14). Split c-myc signals without fusion to IgH were observed in case 2, proving c-myc gene rearrangement and consistent with the t(8;22).
CONCLUSION
These results suggest that c-myc gene alterations may be involved in the pathogenesis of a subset of mature B-cell leukemias with more than 55% prolymphocytes.
DOI：
10.1073/pnas.97.1.228
发表时间：
2000-01-04
影响因子：
11.1
作者：
Shou, YP;Martelli, ML;Kuehl, WM
通讯作者：
Kuehl, WM