Common and distinct neural representations of aversive somatic and visceral stimulation in healthy individuals.
Common and distinct neural representations of aversive somatic and visceral stimulation in healthy individuals.
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DOI：
10.1038/s41467-020-19688-8
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发表时间：
2020-11-23
影响因子：
16.6
通讯作者：
Wager TD
中科院分区：
文献类型：
--
作者：
Van Oudenhove L;Kragel PA;Dupont P;Ly HG;Pazmany E;Enzlin P;Rubio A;Delon-Martin C;Bonaz B;Aziz Q;Tack J;Fukudo S;Kano M;Wager TD
不同类型的疼痛可能被编码在不同的大脑回路中。在这里，我们研究大脑处理内脏和躯体疼痛的异同。我们分析了7个fMRI研究（N = 165）和5种类型的疼痛和不适（食管、胃和直肠膨胀、皮肤热刺激和外阴压力）的数据，以建立和验证可推广的疼痛表征。我们首先评估了一种已建立的多变量脑测量，神经疼痛特征（NPS），作为一种常见的疼痛类型的伤害性疼痛系统。然后，我们开发了一个多变量分类器来区分内脏和躯体疼痛。NPS对98%的疼痛类型的参与者都有强烈的反应，与内脏疼痛和不适的感知强度相关，并且与另外12项研究（N = 180）的认知和情感条件相比，显示出疼痛的特异性。非疼痛负面影响的预定义特征对内脏疼痛没有反应。在交叉验证和独立队列中，内脏与躯体分类器可靠地区分了躯体（热）和内脏（直肠）刺激。其他类型的疼痛反映了躯体和内脏模式的混合。这些结果验证了NPS可以测量不同疼痛类型的共同核心伤害性疼痛系统，并为内脏疼痛和躯体疼痛提供了一种新的分类方法。大脑对不同类型疼痛的处理方式是相似还是不同，目前还不清楚。作者表明，已建立的神经疼痛特征对五种不同类型的内脏和躯体疼痛有反应；他们还开发了一种新的分类器，可以可靠地区分两种疼痛模式。
Different pain types may be encoded in different brain circuits. Here, we examine similarities and differences in brain processing of visceral and somatic pain. We analyze data from seven fMRI studies (N = 165) and five types of pain and discomfort (esophageal, gastric, and rectal distension, cutaneous thermal stimulation, and vulvar pressure) to establish and validate generalizable pain representations. We first evaluate an established multivariate brain measure, the Neurologic Pain Signature (NPS), as a common nociceptive pain system across pain types. Then, we develop a multivariate classifier to distinguish visceral from somatic pain. The NPS responds robustly in 98% of participants across pain types, correlates with perceived intensity of visceral pain and discomfort, and shows specificity to pain when compared with cognitive and affective conditions from twelve additional studies (N = 180). Pre-defined signatures for non-pain negative affect do not respond to visceral pain. The visceral versus the somatic classifier reliably distinguishes somatic (thermal) from visceral (rectal) stimulation in both cross-validation and independent cohorts. Other pain types reflect mixtures of somatic and visceral patterns. These results validate the NPS as measuring a common core nociceptive pain system across pain types, and provide a new classifier for visceral versus somatic pain. Whether the brain processes different types of pain similarly or differently remains unknown. The authors show that an established neurologic pain signature responds to five different types of visceral and somatic pain; they also develop a new classifier that reliably discriminates between both pain modalities.
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DOI：
10.1152/ajpgi.00461.2006
发表时间：
2007-07-01
影响因子：
4.5
作者：
Coen, Steven J.;Gregory, Lloyd J.;Aziz, Qasim
通讯作者：
Aziz, Qasim
影响因子：
2.3
作者：
Cervero, Fernando
通讯作者：
Cervero, Fernando
影响因子：
5.7
作者：
Genovese, CR;Lazar, NA;Nichols, T
通讯作者：
Nichols, T
影响因子：
7.4
作者：
López-Solà M;Woo CW;Pujol J;Deus J;Harrison BJ;Monfort J;Wager TD
通讯作者：
Wager TD
影响因子：
5.7
作者：
Brodersen, Kay H.;Wiech, Katja;Lomakina, Ekaterina I.;Lin, Chia-shu;Buhmann, Joachim M.;Bingel, Ulrike;Ploner, Markus;Stephan, Klaas Enno;Tracey, Irene
通讯作者：
Tracey, Irene