Age-related macular degeneration affects the optic radiation white matter projecting to locations of retinal damage
Age-related macular degeneration affects the optic radiation white matter projecting to locations of retinal damage
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DOI：
10.1007/s00429-018-1702-5
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发表时间：
2018-05
影响因子：
3.1
通讯作者：
Shoyo Yoshimine;S. Ogawa;H. Horiguchi;Masahiko Terao;A. Miyazaki;Kenji Matsumoto;H. Tsuneoka;T. Nakano;Y. Masuda;F. Pestilli
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文献类型：
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作者：
Shoyo Yoshimine;S. Ogawa;H. Horiguchi;Masahiko Terao;A. Miyazaki;Kenji Matsumoto;H. Tsuneoka;T. Nakano;Y. Masuda;F. Pestilli
我们研究了年龄相关性黄斑变性（AMD）对视力和视觉白色物质的影响。我们结合了自适应皮质图谱和弥散加权磁共振成像（dMRI）和纤维束成像，以分离视辐射（OR）投影到人类初级视皮层的不同视网膜偏心率。我们利用已知的解剖组织的OR和临床相关的数据分割成三个主要组成部分投影到中央凹，中部和远周边的OR。我们测量了白色组织的特性-分数各向异性，线性，平面度，球形度-沿上述三个组成部分的光学辐射比较AMD患者和对照组。我们发现，在白色物质属性的差异，具体或白色物质束投射到初级视觉皮层的位置对应的视网膜损伤的位置（中央凹）。此外，我们发现AMD患者的白色物质性质的大小与视力相关。总之，我们证明了AMD患者视力丧失、视网膜损伤的解剖位置和白色物质损伤之间的特定关系。重要的是，我们证明了这些变化是如此深刻，可以使用具有临床分辨率的磁共振成像数据检测到。视网膜和白色物质损害之间的保守映射表明，视网膜神经变性可能是AMD患者白色物质变性的主要原因。结果突出了眼部疾病对脑组织的影响，这一过程可能成为治疗过程中监测的重要目标。
We investigated the impact of age-related macular degeneration (AMD) on visual acuity and the visual white matter. We combined an adaptive cortical atlas and diffusion-weighted magnetic resonance imaging (dMRI) and tractography to separate optic radiation (OR) projections to different retinal eccentricities in human primary visual cortex. We exploited the known anatomical organization of the OR and clinically relevant data to segment the OR into three primary components projecting to fovea, mid- and far-periphery. We measured white matter tissue properties—fractional anisotropy, linearity, planarity, sphericity—along the aforementioned three components of the optic radiation to compare AMD patients and controls. We found differences in white matter properties specific to OR white matter fascicles projecting to primary visual cortex locations corresponding to the location of retinal damage (fovea). Additionally, we show that the magnitude of white matter properties in AMD patients’ correlates with visual acuity. In sum, we demonstrate a specific relation between visual loss, anatomical location of retinal damage and white matter damage in AMD patients. Importantly, we demonstrate that these changes are so profound that can be detected using magnetic resonance imaging data with clinical resolution. The conserved mapping between retinal and white matter damage suggests that retinal neurodegeneration might be a primary cause of white matter degeneration in AMD patients. The results highlight the impact of eye disease on brain tissue, a process that may become an important target to monitor during the course of treatment.