Basal forebrain thermoregulatory mechanism modulates auto-regulated sleep.
Basal forebrain thermoregulatory mechanism modulates auto-regulated sleep.
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基础前脑体温调节机制调节自动调节的睡眠。
DOI：
10.3389/fneur.2012.00102
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发表时间：
2012
影响因子：
3.4
通讯作者：
Kumar VM
中科院分区：
文献类型：
--
作者：
Mallick HN;Kumar VM
调节体温和睡眠是对我们的生存至关重要的两种生理机制。有趣的是，涉及这两种功能的神经结构是共同的。这些区域包括内侧视前区（POA）、外侧视前区、腹外侧视前区、正中视前核和内侧隔，它们构成了基底前脑（BF）的一部分。当给予选择时，大鼠更喜欢呆在27°C的环境温度中，尽管当它们被放置在30°C时观察到最大的睡眠。在所有的睡眠研究中，27℃左右的环境温度应被视为大鼠的热中性温度。在这个温度下，睡眠和体温的昼夜波动得到适当的表达。POA的热敏感神经元在30°C时调节睡眠的增加。在环境温度从27°C上升到30°C期间促进睡眠，具有体温调节功能。核心体温和皮肤温度的自主温度调节变化可以作为调节促进睡眠的大脑区域的神经元活动的输入信号。这些研究表明，脑前神经在调节睡眠中起着关键作用。BF热调节系统是机体内稳态睡眠调节机制的一部分，是一种自动调节的系统。
Regulation of body temperature and sleep are two physiological mechanisms that are vital for our survival. Interestingly neural structures implicated in both these functions are common. These areas include the medial preoptic area (POA), the lateral POA, the ventrolateral POA, the median preoptic nucleus, and the medial septum, which form part of the basal forebrain (BF). When given a choice, rats prefer to stay at an ambient temperature of 27°C, though the maximum sleep was observed when they were placed at 30°C. Ambient temperature around 27°C should be considered as the thermoneutral temperature for rats in all sleep studies. At this temperature the diurnal oscillations of sleep and body temperature are properly expressed. The warm sensitive neurons of the POA mediate the increase in sleep at 30°C. Promotion of sleep during the rise in ambient temperature from 27 to 30°C, serve a thermoregulatory function. Autonomous thermoregulatory changes in core body temperature and skin temperature could act as an input signal to modulate neuronal activity in sleep-promoting brain areas. The studies presented here show that the neurons of the BF play a key role in regulating sleep. BF thermoregulatory system is a part of the global homeostatic sleep regulatory mechanism, which is auto-regulated.