The epithelial tight junction: structure, function and preliminary biochemical characterization.
The epithelial tight junction: structure, function and preliminary biochemical characterization.
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上皮紧密连接：结构、功能和初步生化特征。
DOI：
10.1007/bf00226141
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发表时间：
1988
影响因子：
4.3
通讯作者：
Bullivant,S
中科院分区：
文献类型：
--
作者：
Stevenson,BR;Anderson,JM;Bullivant,S
紧密连接，orzonula occludens（ZO），在大多数脊椎动物上皮细胞的细胞旁通路中形成半渗透屏障。ZO是一系列细胞间连接的最顶端成员，统称为连接复合体，发现于顶端和侧面细胞表面的界面处。这种结构不仅限制了细胞周围物质的运动，而且还可以作为一个“栅栏”来维持上皮细胞的细胞表面组成极性特征。ZO的形态学和生理学已经有了很好的记录，并在这里简要回顾。这个重要的细胞间连接的生物化学仍然在很大程度上是未知的，虽然最近已经确定了一个紧密连接特异性多肽称为“ZO-1”。关于这一外周磷蛋白的生物学ZO的作用的初步观察。
The tight junction, orzonula occludens(ZO), forms a semi-permeable barrier in the paracellular pathway in most vertebrate epithelia. The ZO is the apical-most member of a series of intercellular junctions, collectively known as the junctional complex, found at the interface of the apical and lateral cell surface. This structure not only restricts movement of substances around the cells, but may also serve as a ‘fence’ acting to maintain the cell surface compositional polarity characteristic of epithelial cells. The morphology and physiology of the ZO have been well documented and are briefly reviewed here. The biochemistry of this important intercellular junction remains largely unknown, although a tight junction-specific polypeptide called ‘ZO-1’ has recently been identified. Preliminary observations regarding the role of this peripheral phosphoprotein in the biology of the ZO are presented.