Orbitofrontal Cortex and Olfactory Bulb Volume Predict Distinct Aspects of Olfactory Performance in Healthy Subjects
Orbitofrontal Cortex and Olfactory Bulb Volume Predict Distinct Aspects of Olfactory Performance in Healthy Subjects
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DOI：
10.1093/cercor/bhs230
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发表时间：
2013-10-01
期刊：
影响因子：
3.7
通讯作者：
Lundstroem, Johan N.
中科院分区：
文献类型：
--
作者：
Seubert, Janina;Freiherr, Jessica;Lundstroem, Johan N.
虽然最近的研究表明，一个重要的作用，高级嗅觉脑区的基本嗅觉性能，在何种程度上皮层和外周神经标记占不同部分的嗅觉感知敏锐度的变化仍不清楚。我们通过将90名健康成年人的基于体素的形态测量数据与嗅觉性能指标相关联来解决这个问题。补充这种方法与功能定义的嗅觉皮层区域和嗅球体积的感兴趣区域（ROI）分析，我们试图解开中央和外周区域的相对贡献行为变异。全脑分析显示右侧眶沟的灰质体积和嗅觉功能评分呈显著正相关。ROI分析证实了这一效应，进一步表明嗅觉评分与嗅球体积显著相关。此外，观察到的功能分离，与中央和外周机制解释不同方面的观察到的行为差异的嗅觉子分数。与以前的临床研究一致，这些数据表明，健康个体的右侧眶额皮质和嗅球体积中的区域灰质体积对嗅觉表现具有重要作用。
While recent studies suggest an important role of higher order olfactory brain areas for basic olfactory performance, the extent to which cortical and peripheral neural markers account for separate portions of the variability in olfactory perceptual acuity is still unclear. We addressed this question by correlating voxel-based morphometry data from 90 healthy adults with olfactory performance measures. Supplementing this approach with region of interest (ROI) analyses of functionally defined olfactory cortical regions and olfactory bulb volume, we sought to disentangle the relative contribution of central and peripheral areas to behavioral variability. Whole-brain analyses revealed a significant positive correlation of gray matter volume and olfactory function scores in the right orbital sulcus. This effect was confirmed by the ROI analyses, which further indicated a significant association of the olfactory score with olfactory bulb volume. Moreover, a functional dissociation was observed, with central and peripheral mechanisms explaining different aspects of the observed behavioral variance in the olfactory subscores. In line with previous clinical studies, these data thus suggest an important role of regional gray matter volume in the right orbitofrontal cortex and olfactory bulb volume for olfactory performance in healthy individuals.