Increase in immune cell infiltration with progression of oral epithelium from hyperkeratosis to dysplasia and carcinoma
Increase in immune cell infiltration with progression of oral epithelium from hyperkeratosis to dysplasia and carcinoma
复制标题
DOI：
10.1038/sj.bjc.6600282
复制
发表时间：
2002-05-06
影响因子：
8.8
通讯作者：
Keisari, Y
中科院分区：
文献类型：
--
作者：
Gannot, G;Gannot, I;Keisari, Y
在本研究中，上皮来源的病变的各种病理表现进行了检查组织学和免疫组化的单核细胞浸润。本文对53例角化过度的人舌组织进行了免疫单核细胞成分的研究。轻度异型增生11例（9起案件），中重度异型增生（14例）和方细胞癌对30例腮腺多形性腺瘤（14例）和癌伴多形性腺瘤（16例）的腮腺组织进行了相似分析。免疫组化分析肿瘤浸润免疫细胞的各种表面标志物，并与转化水平定义的形态学和p53在上皮中的表达。结果表明，在舌病变。上皮从正常外观到转化的变化伴随着CD 4、CD 8、CD 14、CD 19+20和HLA/DR阳性细胞浸润的相应增加。最显著的变化是舌病变中B淋巴细胞的增加，这与转化水平一致（P <0.001）在唾液腺中，有相当数量的病例未显示浸润。在存在浸润的病例中，观察到类似的模式，并且恶性程度越高的组织表现出更高程度的免疫细胞浸润，（C）2002年英国癌症研究。
In the present study, epithelium derived lesions of various pathological manifestations were examined histologically and immunchistochemically for mononuclear cell infiltration. The infiltrate under the transformed epithelium of oral lesions, was examined for differences in the composition of immune mononuclear cells as the epithelium moves from hyperkeratosis through various degrees of dysplasia to squamous cell carcinoma The study was performed on 53 human tongue tissues diagnosed as hyperkeratosis (11 cases), mild dysplasia (nine cases), moderate and severe dysplasia (14 cases) and squarrous cell carcinoma (19 cases) A similar analysis was performed on 30 parotid gland tissues diagnosed as pleomorphic adenoma (14 cases) and carcinoma ex-pleomorphic adenoma (16 cases). Immunohistochemical analysis of various surface markers of the tumour infiltrating immune cells was performed and correlated with the transformation level as defined by morphology and the expression of p53 in the epithelium, The results revealed that, in the tongue lesions. the changes in the epithelium from normal appearance to transformed were accompanied by a corresponding Increase in the infiltration of CD4, CD8, CD 14, CD 19+20, and HLA/DR positive cells. The most significant change was an Increase in B lymphocytes in tongue lesions, that was in accordance with the transformation level (P < 0 00 1) In the salivary gland, a significant number of cases did not show an infiltrate In cases where an infiltrate was present, a similar pattern was observed and the more malignant tissues exhibited a higher degree of immune cell infiltration, (C) 2002 Cancer Research UK.