Metal compounds in cancer chemotherapy
Metal compounds in cancer chemotherapy
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DOI：
10.1016/0010-8545(90)80065-2
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发表时间：
1990-03
影响因子：
20.6
通讯作者：
I. Haiduc;C. Silvestru
中科院分区：
文献类型：
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作者：
I. Haiduc;C. Silvestru
化疗是对抗癌症的主要武器之一。直到最近，大多数抗肿瘤药物是有机化合物或天然产物，包括烷基化剂、抗生素、生物碱、酶和激素。无机化合物，尤其是含金属化合物，由于大多数金属被认为是潜在的致癌物，因此没有得到系统的研究。1969年Rosenberg等人发现铂配合物具有抗肿瘤作用[I]。随着这一发现，这一领域的研究出现了爆炸式增长。作为第一个主要结果，最早的铂配合物之一，顺-二氨二氯铂（II），cam-[Pt（NH~）* Cl~]（I），后来被称为顺铂，通过了所有筛选
Chemotherapy is one of the main weapons in the fight against cancer. Until recently the majority of antitumor drugs were organic compounds or natural products including alkylating agents, antibiotics, alkaloids, enzymes and hormones. Inorganic compounds, especially metal-containing compounds, were not systematically investigated since most metals were considered to be potential carcinogens.A crucial event happened in 1969 when Rosenberg et al. discovered that platinum complexes exhibit a~ titumor properties [I]. Following this discovery, an explosion of research occurred in this area. As a first major result, one of the earliest platinum complexes, cis-diamminedichloroplatinum (II), cam-[Pt (NH~)* Cl~](I), later known as cisplatin, has passed all the screening