Pharmaceuticals and personal care products in water, sediments, aquatic organisms, and fish feeds in the Pearl River Delta: Occurrence, distribution, potential sources, and health risk assessment
Pharmaceuticals and personal care products in water, sediments, aquatic organisms, and fish feeds in the Pearl River Delta: Occurrence, distribution, potential sources, and health risk assessment
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珠江三角洲水体、沉积物、水生生物和鱼饲料中的药品和个人护理品：发生、分布、潜在来源和健康风险评估
DOI：
10.1016/j.scitotenv.2018.12.222
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发表时间：
2019
影响因子：
9.8
通讯作者：
Wong Minghung
中科院分区：
文献类型：
--
作者：
Xie Haiwen;Hao Hongshan;Xu Nan;Liang Xinxiu;Gao Dingxue;Xu Yaru;Gao Yue;Tao Huchun;Wong Minghung
本研究调查了珠江三角洲海水养殖区水体、沉积物、水生生物(鱼类和贝类)和鱼类饲料中34种药物和个人护理产品(PPCPs)的存在、分布和潜在来源。还评估了这类化合物的健康风险与其通过海鲜消费摄入的关系。在34种PPCPs中，在水、沉积物、鱼饲料和水生生物中分别检测到9、21、14和28种PPCPs。所有基质中均检出甲氧苄氨嘧啶、诺氟沙星、氧氟沙星和壮观霉素。水样和沉积物中的PPCPs水平相对较低。大观霉素、扑热息痛、环丙沙星、诺氟沙星和布洛芬是饲料中最常见的PPCPs。布洛芬和酮洛芬在水生生物中广泛存在，平均浓度分别为562和267 ng/g湿重。多氯联苯在贻贝(贻贝)和牡蛎(牡蛎)等贝类中的残留量(p<； )显著高于其他物种(石斑鱼)和石斑鱼(EO)。相关分析表明，药剂饲料是珠江三角洲海水养殖区PPCPs的潜在来源，但其他人为来源也不容忽视。根据最大残留限量和每日可接受摄入量，食用海鲜给人类带来的健康风险可以忽略不计。然而，由于在水产养殖环境、水生生物和饲料中经常检测到多种抗生素，水产养殖中与抗生素使用相关的抗菌素耐药性的诱导和传播将受到极大的关注。要建立集中管理制度，控制海水养殖中兽药的使用，保护水产养殖环境，确保海产品安全。
This study investigated the occurrence, distribution, and potential sources of 34 pharmaceuticals and personal care products (PPCPs) in water, sediments, aquatic organisms (fish and shellfish), and fish feeds from the mariculture areas of the Pearl River Delta (PRD). The health risk presented by this class of compounds was also assessed in relation to their intake via seafood consumption. Of the 34 PPCPs, a total of 9, 21, 14, and 28 PPCPs were detected in water, sediments, fish feeds, and aquatic organisms, respectively. Trimethoprim, norfloxacin, ofloxacin, and spectinomycin were detected in all matrices. The levels of PPCPs in water and sediment samples were relatively low. Spectinomycin, paracetamol, ciprofloxacin, norfloxacin, and ibuprofen were the most frequently detected PPCPs in feeds. Ibuprofen and ketoprofen were widely detected in aquatic organisms, with average concentrations of 562 and 267 ng/g wet weight, respectively. The residual levels of PPCPs in shellfish such as ME (mussel,Mytilus edulis) and OS (oyster,Ostrea gigas) were significantly higher (p< 0.05) than those in other species including CA (topmouth culter,Culter alburnus) and EO (orbfish,Ephippus orbis). Correlation analysis indicated that the medicated feeds were a potential source of PPCPs in the mariculture areas of the PRD, but other anthropogenic sources should not be ignored. Based on maximum residue limits and acceptable daily intake, the health risks presented to humans via seafood consumption are negligible. However, as multiple antibiotics were frequently detected in the mariculture environment, aquatic organisms, and feeds, the induction and dissemination of antimicrobial resistance associated with antibiotic usage in aquaculture would be of great concern. It is necessary to establish a centralized management system and control the use of veterinary drugs in mariculture to protect the aquaculture environment and ensure the safety of seafood.