The D2 dopamine receptor (DRD2) gene is associated with co-morbid depression, anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder
The D2 dopamine receptor (DRD2) gene is associated with co-morbid depression, anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder
复制标题
DOI：
10.1016/j.eurpsy.2005.01.006
复制
发表时间：
2006-04-01
影响因子：
7.8
通讯作者：
Ritchie, T
中科院分区：
文献类型：
--
作者：
Lawford, BR;Young, R;Ritchie, T
目标。-根据症状特征确定创伤后应激障碍（PTSD）患者群，并检查多巴胺受体（DRD2）基因的a1等位基因与这些群的关系。-对57名患有创伤后应激障碍的未经治疗的白人越战退伍军人进行一般健康问卷-28 （GHQ）和密西西比战争相关创伤后应激障碍量表。pcr检测DRD2等位基因状态。携带DRD2 A1等位基因的受试者在GHQ 2（焦虑/失眠）、GHQ 3（社交功能障碍）和GHQ 4（抑郁）方面的得分明显高于没有该等位基因的受试者。GHQ数据的聚类分析确定了两个主要群体。一个高精神病理集群（集群3），以躯体关注、焦虑/失眠、社交功能障碍和抑郁的高共病水平为特征，一个低精神病理集群（集群1），表现为相反的模式。4个GHQ组的得分在第三组明显高于第一组，密西西比量表PTSD得分也是如此。DRD2 A1等位基因的高发者比无该等位基因的高发者更有可能出现在精神病理高群中。DRD2变异与PTSD患者严重的共病性精神病理相关。(c) 2005 Elsevier SAS。版权所有。
Objective. - To identify clusters of patients with post-traumatic stress disorder (PTSD) according to symptom profile and to examine the association of the A I allele of the D, dopamine receptor (DRD2) gene with these clusters.Method. - Fifty-seven untreated Caucasian Vietnam veterans with PTSD were administered the General Health Questionnaire-28 (GHQ) and the Mississippi Scale for combat-related PTSD. DRD2 allelic status was determined by PCR.Results. - Subjects with the DRD2 A1 allele compared to those without this allele had significantly higher scores on GHQ 2 (anxiety/insomnia), GHQ 3 (social dysfunction) and GHQ 4 (depression). Cluster analysis of the GHQ data identified two primary groups. A high psychopathology cluster (cluster 3), featured by high co-morbid levels of somatic concerns, anxiety/insomnia, social dysfunction and depression, and a low psychopathology cluster (cluster 1), manifested by the reverse pattern. Scores in each of the four GHQ groups were significantly higher in cluster 3 than cluster 1, as was Mississippi Scale PTSD score. DRD2 A1 allele veterans compared to those without this allele were significantly more likely to be found in the high than the low psychopathology cluster group.Conclusions. - DRD2 variants are associated with severe co-morbid psychopathology in PTSD subjects. (c) 2005 Elsevier SAS. All rights reserved.