Neurovestibular modulation of circadian and homeostatic regulation: Vestibulohypothalamic connection?
Neurovestibular modulation of circadian and homeostatic regulation: Vestibulohypothalamic connection?
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DOI：
10.1073/pnas.242251499
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发表时间：
2002-11-26
影响因子：
11.1
通讯作者：
Fuller, CA
中科院分区：
文献类型：
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作者：
Fuller, PM;Jones, TA;Fuller, CA
长期暴露于加力环境(+G)对体温(T-b)、活动(ACT)、心率、摄食和肥胖的昼夜节律和动态平衡调节有显著影响。通过使用缺乏前庭毛细胞的BRN 3.1基因敲除小鼠，我们最近描述了前庭系统在调节一些适应性反应中的主要作用。本研究以缺乏黄斑性耳锥的C57BL/6JEI-HET小鼠品系(HET)为研究对象，探讨前庭特异性受体的作用。本研究通过慢性离心法将8只HET和8只WT小鼠暴露于2G中8周。此外，在类似条件下，8只HET和8只WT小鼠作为1G对照组。在2G暴露后，WT表现出结核病的减少和减弱的结核病昼夜节律。表演手段和节奏也有所减弱。体重和食物摄入量显著低于1G对照组。8周后，WT组小鼠的体脂百分比显著降低(P<；0.0001)。相反，HET组小鼠的平均T-b没有下降，仅有轻微的T-b昼夜节律幅度下降。HET Act水平的降低程度与WT小鼠相似。HET组小鼠的体重和食物摄入量仅略有减少，8周后，2G HET组的体脂百分比没有变化。这些结果将前庭黄斑受体与动态平衡和昼夜节律的特定变化联系起来。
Chronic exposure to increased force environments (+G) has pronounced effects on the circadian and homeostatic regulation of body temperature (T-b), ambulatory activity (Act), heart rate, feeding, and adiposity. By using the Brn 3.1 knockout mouse, which lacks vestibular hair cells, we recently described a major role of the vestibular system in mediating some of these adaptive responses. The present study used the C57BL/6JEi-het mouse strain (het), which lacks macular otoconia, to elucidate the contribution of specific vestibular receptors. In this study, eight het and eight WT mice were exposed to 2G for 8 weeks by means of chronic centrifugation. In addition, eight het and eight WT mice were maintained as 1G controls in similar conditions. Upon 2G exposure, the WT exhibited a decrease in Tb and an attenuated Tb circadian rhythm. Act means and rhythms also were attenuated. Body mass and food intake were significantly lower than the 1G controls. After 8 weeks, percent body fat was significantly lower in the WT mice (P < 0.0001). In contrast, the het mice did not exhibit a decrease in mean T-b and only a slight decrease in T-b circadian amplitude. het Act levels were attenuated similarly to the WT mice. Body mass and food intake were only slightly attenuated in the het mice, and percent body fat, after 8 weeks, was not different in the 2G het group. These results link the vestibular macular receptors with specific alterations in homeostatic and circadian regulation.