Chemical-Induced Vitiligo.
Chemical-Induced Vitiligo.
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DOI：
10.1016/j.det.2016.11.006
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发表时间：
2017-04
影响因子：
2.4
通讯作者：
Harris JE
中科院分区：
文献类型：
--
作者：
Harris JE
由化学物质引起的皮肤脱色已经被认识到超过75年了，最初是一种职业危害，但后来扩展到那些使用像染发剂这样常见的家用商业产品的人。自从他们发现以来，这些化学物质已经被用于治疗严重白癜风患者，以使他们剩余的皮肤脱色，改善他们的外表。认识到这一现象的重要性在2013年夏天日本白癜风暴发期间得到了突显，当时一种新的皮肤美白化妆品霜的1.6万多名用户在接触霜的地方和许多偏远地区的人出现了皮肤脱色。脱色化学物质似乎是氨基酸酪氨酸的类似物，它可以扰乱黑色素的生成，导致自身免疫和黑素细胞的破坏。由于化学诱导的色素脱失在临床和组织学上与非化学诱导的白癜风难以区分，而且这些化学物质似乎可以诱导黑素细胞的自身免疫，这种现象应该被称为化学诱导的白癜风，而不是以前使用的不太准确的术语。
Chemical-induced depigmentation of the skin has been recognized for over 75 years, first as an occupational hazard but then extending to those using household commercial products as common as hair dyes. Since their discovery, these chemicals have been used therapeutically in patients with severe vitiligo to depigment their remaining skin and improve their appearance. The importance of recognizing this phenomenon was highlighted during an outbreak of vitiligo in Japan during the summer of 2013, when over 16,000 users of a new skin lightening cosmetic cream developed skin depigmentation at the site of contact with the cream and many in remote areas as well. Depigmenting chemicals appear to be analogs of the amino acid tyrosine that disrupt melanogenesis and result in autoimmunity and melanocyte destruction. Because chemical-induced depigmentation is clinically and histologically indistinguishable from non-chemically induced vitiligo, and because these chemicals appear to induce melanocyte autoimmunity, this phenomenon should be known as “chemical-induced vitiligo”, rather than less accurate terms that have been previously used.