Common Variants of the Thyroglobulin Gene Are Associated with Differentiated Thyroid Cancer Risk
Common Variants of the Thyroglobulin Gene Are Associated with Differentiated Thyroid Cancer Risk
复制标题
DOI：
10.1089/thy.2010.0384
复制
发表时间：
2011-05-01
期刊：
影响因子：
6.6
通讯作者：
Velazquez, Antonia
中科院分区：
文献类型：
--
作者：
Akdi, Abdelmounaim;Perez, Gisselle;Velazquez, Antonia
背景：遗传因素在甲状腺癌易感性中是重要的。最近，有报道称，某些染色体区域与甲状腺癌有关。本研究采用病例对照研究方法，探讨分化型甲状腺癌（DTC）与染色体8 q区域变异之间的关系。方法：采用病例对照研究设计，对877名个体（398例散发性DTC患者和479名健康对照）进行研究。iPLEX技术应用于分析染色体8 q中的7个单核苷酸多态性（SNP）：2个SNP位于8 q24，先前报道为不同类型癌症的风险标志物，2个SNP位于促甲状腺激素释放激素受体基因（TRHR），3个SNP位于甲状腺球蛋白基因（TG）。结果：在8 q24区域发现的两个SNPs位点rs6983267和rs 1447295以及TRHR基因多态性与DTC无相关性。外显子33 TG多态性也没有发现关联。然而，外显子10-12簇中的两个TG多态性与DTC风险增加相关（显性模型比值比=1.80，95%置信区间=1.30-2.50，p
Background: Genetic factors are important in thyroid cancer susceptibility. Recently, it has been reported that there are associations of certain chromosome regions with thyroid cancer. In this case-control study, we sought to determine whether there is an association between differentiated thyroid cancer (DTC) and variants in regions of chromosome 8q.Methods: We used a case-control association design in a population of 877 individuals (398 patients with sporadic DTC and 479 healthy controls). The iPLEX technology was applied to analyze seven single-nucleotide polymorphisms (SNPs) in chromosome 8q: two SNPs that map at 8q24, previously reported as risk markers in different types of cancer, two SNPs in the thyrotropin-releasing hormone receptor gene (TRHR), and three SNPs in the thyroglobulin gene (TG). Risk assessment was done by unconditional regression analysis.Results: The two SNPs that map at 8q24, rs6983267 and rs1447295, and the two TRHR polymorphisms showed no association with DTC. No association was also found for the exon 33 TG polymorphism. The two TG polymorphisms in the exon 10-12 cluster, however, were associated with an increased risk of DTC (dominant model odds ratio=1.80, 95% confidence interval =1.30-2.50, p