Cytological regression and clearance of high-risk human papillomavirus in women with an abnormal cervical smear
Cytological regression and clearance of high-risk human papillomavirus in women with an abnormal cervical smear
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DOI：
10.1016/s0140-6736(01)06809-x
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发表时间：
2001-11-24
期刊：
影响因子：
168.9
通讯作者：
Meijer, CJLM
中科院分区：
文献类型：
--
作者：
Nobbenhuis, MAE;Helmerhorst, TJM;Meijer, CJLM
我们研究了高危型人乳头瘤病毒（HPV）感染的自然病程和因宫颈涂片异常而接受阴道镜检查的妇女的细胞学消退。我们发现高危HPV清除平均比宫颈病变消退提前3个月。轻度和中度核异常宫颈涂片妇女的细胞学消退的累积一年率相似。因此，在轻度至中度核异常的女性中，6个月后重新检测高危HPV可预测细胞学消退。
We studied the natural course of high-risk human papillomavirus (HPV) infection and cytological regression in women referred for colposcopy because of abnormal cervical smears. We found that high-risk HPV clearance preceded regression of cervical lesions by an average of 3 months. The cumulative I-year rate of cytological regression was similar in women with mild and moderate dyskaryotic cervical smears. Thus, retesting of high-risk HPV after 6 months in women with mild to moderate dyskaryosis predicts cytological regression.