Cross-species homology of the CLN3 gene.
Cross-species homology of the CLN3 gene.
复制标题
CLN3 基因的跨物种同源性。
DOI：
10.1055/s-2007-973658
复制
发表时间：
1997
期刊：
影响因子：
1.4
通讯作者：
Breuning,MH
中科院分区：
文献类型：
--
作者：
Taschner,PE;deVos,N;Breuning,MH
通过用人CLN3 cDNA筛选小鼠cDNA文库来分离鼠cDNA克隆。序列分析表明，CLN3蛋白具有高度同源性。我们将这些序列与最近从狗身上发现的CLN3序列进行了比较。elegans和面包酵母S.啤酒。CLN3蛋白在真核生物物种中是非常保守的。可能对蛋白质的功能至关重要的几个蛋白质修饰位点是保守的。
A murine cDNA clone was isolated by screening a mouse cDNA library with the human CLN3 cDNA. Sequence analysis indicates that the corresponding CLN3 proteins are highly homologous. We have compared these with recently identified CLN3 sequences from the dog, the nematode C. elegans, and baker's yeast S. cerevisiae. The CLN3 protein is remarkably conserved across eukaryotic species. Several protein modification sites which may be crucial for the function of the protein are conserved.