INDUCTION OF PHYSICAL-DEPENDENCE IN RATS BY ETHANOL INHALATION WITHOUT USE OF PYRAZOLE
INDUCTION OF PHYSICAL-DEPENDENCE IN RATS BY ETHANOL INHALATION WITHOUT USE OF PYRAZOLE
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DOI：
10.1016/0041-008x(77)90097-7
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发表时间：
1977-01-01
影响因子：
3.8
通讯作者：
BOBYOCK, E
中科院分区：
文献类型：
--
作者：
FERKO, AP;BOBYOCK, E
在不使用吡唑的情况下，将大鼠暴露于浓度不断增加的空气乙醇（14-28 mg/L）中10天。有上升的空气中的乙醇浓度和血液中的乙醇浓度之间的正相关性。在第10天，将动物从室中取出，平均血液乙醇浓度为3.13 mg/ml，并在24小时内观察戒断体征。在此期间，所有动物在处理时均表现出自发性戒断和惊厥体征。处理时自发体征和惊厥之间呈正相关。乙醇从血液中的消失在最初的7小时内遵循0级动力学。在停药阶段，血液乙醇浓度的下降与处理时抽搐评分的上升之间存在明确的负相关性。该吸入程序是一种简单、可重复的方法，可在不使用吡唑的情况下引起大鼠对乙醇的身体依赖，并保持原始体重。
Rats were exposed to increasing air ethanol concentrations (14-28 mg/liter) over a 10-day period without the use of pyrazole. There was a positive correlation between the rising air ethanol concentrations in the chamber and the concentrations of ethanol in the blood. On the 10th day the animals were removed from the chamber with a mean blood ethanol concentration of 3.13 mg/ml and observed for signs of withdrawal over a 24-h period. During this time all animals manifested spontaneous signs of withdrawal and convulsions on handling. There was a positive correlation between the spontaneous signs and convulsions on handling. The disappearance of ethanol from the blood followed 0-order kinetics over the first 7 h. In the withdrawal phase a definite negative correlation existed between the decreasing blood ethanol concentrations and the rise in scores for convulsions on handling. This inhalation procedure was a simple, reproducible approach for causing physical dependence on ethanol in rats without the use of pyrazole and with the maintenance of original body wt.