Targeting specific cell organelles with different-faceted nanocrystals that are selectively recognized by organelle-targeting peptides.
Targeting specific cell organelles with different-faceted nanocrystals that are selectively recognized by organelle-targeting peptides.
复制标题
DOI：
10.1039/d0cc02930k
复制
发表时间：
2020-06
影响因子：
4.9
通讯作者：
Qilin Yu;Guizhu Wu;Tong Zhang;Xudong Zhao;Zhen Zhou;Lu Liu;Wei Chen;P. Alvarez
中科院分区：
文献类型：
--
作者：
Qilin Yu;Guizhu Wu;Tong Zhang;Xudong Zhao;Zhen Zhou;Lu Liu;Wei Chen;P. Alvarez
靶向特定的细胞器是一个难以实现的治疗目标，可以通过操纵纳米晶面来实现。作为概念的证明，不同的小平面工程纳米棒(高能(001)镉和(001)镉，以及低能(101)镉和(110)镉)利用细胞器靶向多肽的选择性结合和随后的细胞内蛋白质分选来抑制特定的细胞器，而没有显著的细胞毒性。
Targeting specific cellular organelles is an elusive therapeutic goal that could be achieved by manipulating nanocrystal facets. As proof of concept, different facet-engineered nanonods (high-energy (001) CdS and (001) CdSe, and low-energy (101) CdS and (110) CdSe) exploited selective binding by organelle-targeting peptides and subsequent intracellular protein sorting to inhibit specific organelles without significant cytotoxicity.